ID   EIF3K_ASPFC             Reviewed;         249 AA.
AC   B0XY69;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit K {ECO:0000255|HAMAP-Rule:MF_03010};
DE            Short=eIF3k {ECO:0000255|HAMAP-Rule:MF_03010};
DE   AltName: Full=eIF-3 p25 {ECO:0000255|HAMAP-Rule:MF_03010};
GN   ORFNames=AFUB_039840;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03010}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03010}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03010}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit K family. {ECO:0000255|HAMAP-
CC       Rule:MF_03010}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDP52815.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; DS499596; EDP52815.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; B0XY69; -.
DR   SMR; B0XY69; -.
DR   PhylomeDB; B0XY69; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006446; P:regulation of translational initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.250; -; 1.
DR   HAMAP; MF_03010; eIF3k; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   InterPro; IPR009374; eIF3k.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR016020; Transl_init_fac_sub12_N_euk.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13022; PTHR13022; 1.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..249
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   K"
FT                   /id="PRO_0000365052"
FT   DOMAIN          46..222
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   249 AA;  27972 MW;  935C396F0477A2BF CRC64;
     MGVAFDKCDT RPAHIDAILN GLDRYNPETT TVFQDYVVQQ CEERTFDCYA NLALLKLYQF
     NPHLLQPETV TNILAKALTV FPSPAFSLCL ALLPAHTQPF PTADTDASQT SDFVESIQKL
     ARLSTLLESA QYAQFWSTLN SDDLYADLVA DVAGFEELVR IRIAIEVGKA FREINAEVLE
     QWLDLRSREA LEKFVTEVCS WEVDKTGPNG TVVKVPTNKE NEARSEVKSE RVGVEMFGRV
     IRRGFEQAA