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EIF3K_CAEEL
ID   EIF3K_CAEEL             Reviewed;         240 AA.
AC   Q9XUP3; Q0VI97;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit K {ECO:0000255|HAMAP-Rule:MF_03010};
DE            Short=eIF3k {ECO:0000255|HAMAP-Rule:MF_03010};
DE   AltName: Full=eIF-3 p25 {ECO:0000255|HAMAP-Rule:MF_03010};
GN   Name=eif-3.K {ECO:0000255|HAMAP-Rule:MF_03010}; ORFNames=pgn-69, T16G1.11;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Chen J.-Y., Chen R.-H., Wu Y.-C.;
RT   "Molecular characterization of eIF-3.K in Caenorhabditis elegans.";
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03010}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03010}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03010}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit K family. {ECO:0000255|HAMAP-
CC       Rule:MF_03010}.
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DR   EMBL; AY731377; AAW63419.1; -; mRNA.
DR   EMBL; Z81592; CAB04732.1; -; Genomic_DNA.
DR   PIR; T24957; T24957.
DR   RefSeq; NP_506241.1; NM_073840.5.
DR   AlphaFoldDB; Q9XUP3; -.
DR   SMR; Q9XUP3; -.
DR   BioGRID; 44798; 17.
DR   DIP; DIP-26400N; -.
DR   IntAct; Q9XUP3; 2.
DR   STRING; 6239.T16G1.11; -.
DR   EPD; Q9XUP3; -.
DR   PaxDb; Q9XUP3; -.
DR   PeptideAtlas; Q9XUP3; -.
DR   EnsemblMetazoa; T16G1.11.1; T16G1.11.1; WBGene00001233.
DR   GeneID; 179779; -.
DR   KEGG; cel:CELE_T16G1.11; -.
DR   UCSC; T16G1.11; c. elegans.
DR   CTD; 179779; -.
DR   WormBase; T16G1.11; CE20081; WBGene00001233; eif-3.K.
DR   eggNOG; KOG3252; Eukaryota.
DR   GeneTree; ENSGT00390000009409; -.
DR   HOGENOM; CLU_076723_1_0_1; -.
DR   InParanoid; Q9XUP3; -.
DR   OMA; WKHQGQG; -.
DR   OrthoDB; 1576799at2759; -.
DR   PhylomeDB; Q9XUP3; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR   PRO; PR:Q9XUP3; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00001233; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:WormBase.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IMP:WormBase.
DR   GO; GO:0006446; P:regulation of translational initiation; IEA:InterPro.
DR   GO; GO:0006413; P:translational initiation; ISS:WormBase.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.250; -; 1.
DR   HAMAP; MF_03010; eIF3k; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   InterPro; IPR009374; eIF3k.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR016020; Transl_init_fac_sub12_N_euk.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13022; PTHR13022; 1.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 2.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..240
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   K"
FT                   /id="PRO_0000123549"
FT   DOMAIN          41..221
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   240 AA;  27031 MW;  E09C2E987251EEEB CRC64;
     MSFEKLQKEL HEAIEGVNRY NPENVADLAA CVQAMVNENK YDKDIVLTIL KLYQLNPEKY
     DEAVVRQVLL KTLMVLPSSD FALAKCLIDT NRLGSQELRR IFDLGAVLES CNFAVFWKLV
     KGAYKPTTNP NEPFKVPGEV PKMIKPMVGF EDAVKHYACR VISVTFQKIE KKMLSRLLGG
     ASDKEVTALA QSFGWEAKEN GDVFFVANHE GTIKTRNIDE KIQFPHVADL LTSIQPPLTL
 
 
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