ID   EIF3K_DANRE             Reviewed;         219 AA.
AC   Q567V6;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit K {ECO:0000255|HAMAP-Rule:MF_03010};
DE            Short=eIF3k {ECO:0000255|HAMAP-Rule:MF_03010};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 12 {ECO:0000255|HAMAP-Rule:MF_03010};
DE   AltName: Full=eIF-3 p25 {ECO:0000255|HAMAP-Rule:MF_03010};
GN   Name=eif3k; Synonyms=eif3s12; ORFNames=zgc:110726;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03010}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC       eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC       eif3m. {ECO:0000255|HAMAP-Rule:MF_03010}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03010}.
CC       Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03010}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit K family. {ECO:0000255|HAMAP-
CC       Rule:MF_03010}.
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DR   EMBL; BC093002; AAH93002.1; -; mRNA.
DR   RefSeq; NP_001017583.1; NM_001017583.1.
DR   AlphaFoldDB; Q567V6; -.
DR   SMR; Q567V6; -.
DR   STRING; 7955.ENSDARP00000089482; -.
DR   PaxDb; Q567V6; -.
DR   GeneID; 550245; -.
DR   KEGG; dre:550245; -.
DR   CTD; 27335; -.
DR   ZFIN; ZDB-GENE-050417-45; eif3k.
DR   eggNOG; KOG3252; Eukaryota.
DR   InParanoid; Q567V6; -.
DR   OrthoDB; 1576799at2759; -.
DR   PhylomeDB; Q567V6; -.
DR   Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DRE-72649; Translation initiation complex formation.
DR   Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DRE-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-DRE-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   PRO; PR:Q567V6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006446; P:regulation of translational initiation; IEA:InterPro.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.250; -; 1.
DR   HAMAP; MF_03010; eIF3k; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   InterPro; IPR009374; eIF3k.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR016020; Transl_init_fac_sub12_N_euk.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13022; PTHR13022; 1.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..219
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   K"
FT                   /id="PRO_0000365031"
FT   DOMAIN          43..205
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   219 AA;  25427 MW;  3DFA39F42B147012 CRC64;
     MATTFEQMRA NVGKLLRGID RYNPENLATL ERYVDTQARE NAYDLEANLA VLKLYQFNLA
     YFQTTVTAQI LLKALTNLPH TDFTLCKCMI DQTHQEERPI RQILYLGNLL ETCHFQSFWA
     SLEENRDLID GITGFEESVR KFICHVVGIT YQNIEYRLLA EMLGDPLDTQ VKVWMNKYGW
     TENEDGQIFI HNQEESVKPK NIVEKIDFES VSSIMATSQ