EIF3K_NEMVE
ID EIF3K_NEMVE Reviewed; 216 AA.
AC A7SGZ5;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit K {ECO:0000255|HAMAP-Rule:MF_03010};
DE Short=eIF3k {ECO:0000255|HAMAP-Rule:MF_03010};
DE AltName: Full=eIF-3 p25 {ECO:0000255|HAMAP-Rule:MF_03010};
GN ORFNames=v1g170558;
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6;
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03010}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03010}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03010}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit K family. {ECO:0000255|HAMAP-
CC Rule:MF_03010}.
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DR EMBL; DS469656; EDO37003.1; -; Genomic_DNA.
DR RefSeq; XP_001629066.1; XM_001629016.1.
DR AlphaFoldDB; A7SGZ5; -.
DR SMR; A7SGZ5; -.
DR STRING; 45351.EDO37003; -.
DR EnsemblMetazoa; EDO37003; EDO37003; NEMVEDRAFT_v1g170558.
DR GeneID; 5508490; -.
DR KEGG; nve:5508490; -.
DR eggNOG; KOG3252; Eukaryota.
DR HOGENOM; CLU_076723_1_0_1; -.
DR InParanoid; A7SGZ5; -.
DR OMA; WKHQGQG; -.
DR OrthoDB; 1576799at2759; -.
DR PhylomeDB; A7SGZ5; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.25.40.250; -; 1.
DR HAMAP; MF_03010; eIF3k; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR InterPro; IPR009374; eIF3k.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR016020; Transl_init_fac_sub12_N_euk.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13022; PTHR13022; 1.
DR Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..216
FT /note="Eukaryotic translation initiation factor 3 subunit
FT K"
FT /id="PRO_0000365034"
FT DOMAIN 40..202
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 216 AA; 24171 MW; DD3D71DF21DA4722 CRC64;
MAAEMRVTVS QLLKGIDRYN PENLKVLEHY VHLQVHENAY DLDANLAVLK LYQFNPAYSQ
TSVISQILLK ALMNLPNADF IMCRCVIDDA IQQDLTIKKV ILLAERLETC AFTSAWQFIK
EEASLVDGVT GFHDAIRNYI TYVIGVTYQT IEESLASELL GGLQGAQLQD WIKAKGWMSS
DDGTIYVTNQ EAHIKSKNIA EKIDFASVAN IIAAAR