ID   EIF3L_AEDAE             Reviewed;         537 AA.
AC   Q16FL6;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=AAEL009617, AAEL014715;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; CH478416; EAT33027.1; -; Genomic_DNA.
DR   EMBL; CH477597; EAT38507.1; -; Genomic_DNA.
DR   RefSeq; XP_001649423.1; XM_001649373.1.
DR   RefSeq; XP_001653862.1; XM_001653812.1.
DR   AlphaFoldDB; Q16FL6; -.
DR   SMR; Q16FL6; -.
DR   STRING; 7159.AAEL009617-PA; -.
DR   GeneID; 5572195; -.
DR   KEGG; aag:5572195; -.
DR   VEuPathDB; VectorBase:AAEL014715; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; Q16FL6; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; Q16FL6; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..537
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364239"
FT   DOMAIN          301..513
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   537 AA;  63471 MW;  B003CC6C918E7F23 CRC64;
     MYSNENYAEE GYEDYGYDAG MIDDGYDRSY YPMHEDVKKF LVYFSSVIKN GVVYEIQNLY
     ENTFPKLSEQ HFEKKAWPSE EEVAHLVDND SLFMILYKEL YYRHLHARIQ KGPSLEQRLN
     SFYNYCNFFN HILPSKEPVQ LELPDIWLWE LIDEFVYQFQ NFAQYRARLS DKSEEEMDML
     LNNNSKVWNI LCILNVLHSL VSMSKIKDQL EAAAAGRDPE EVAGEFGRHS FYKMLGYFSL
     VGLLRVHSLL GDYHQAIKVL EPIEIHKKSQ YSHIPACQIS TSYYVGFAYM MMRRYSDAIR
     TFSSILLYIQ RTKQLYSARS YQNDQINKQT DQMYHLLAIC LVLHPQCIDE SIQQVLREKN
     YHDNMYKMQC GDLETFRNFF VFACPKFVSP VPPPSDAPID DYVKEALEHQ TNVFMDEVRQ
     QQELPTIRSY LKLYTTLPLL KLASFMDHIP QDEIGEQKIE NLLTHLLCFK HKMKNIVWTK
     GASGLEGKFQ SGSELDFYID KDMIHIADTK VSHRYGDFFI RKIMKFEDLN RRLHNLK