ID   EIF3L_ANOGA             Reviewed;         539 AA.
AC   Q7Q5Y8;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 3.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=AGAP006130;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; AAAB01008960; EAA10850.3; -; Genomic_DNA.
DR   RefSeq; XP_316190.3; XM_316190.3.
DR   AlphaFoldDB; Q7Q5Y8; -.
DR   SMR; Q7Q5Y8; -.
DR   STRING; 7165.AGAP006130-PA; -.
DR   PaxDb; Q7Q5Y8; -.
DR   PRIDE; Q7Q5Y8; -.
DR   GeneID; 1276800; -.
DR   KEGG; aga:AgaP_AGAP006130; -.
DR   CTD; 1276800; -.
DR   VEuPathDB; VectorBase:AGAP006130; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; Q7Q5Y8; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; Q7Q5Y8; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..539
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364240"
FT   DOMAIN          302..514
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   539 AA;  63687 MW;  7A7D27846E54EF54 CRC64;
     MYSNEEPWEG GYDEYGYEMG MPEDGMYDRG YFPMHEDVKK FLMYFCTVIK DGVVYEIQNL
     YENTFPKLSE QHFEKKAWPS EEEVAHLVDN DNLFLILYKE LYYRHLHARI QGGPSLEQRL
     NSFYNYCNFF NYILPSKEPV QLELPDIWLW ELIDEFVYQF QNFAQYRARL TDKTDEEMDM
     LLNNNSKVWN ILCILNVLHS LVSMSKIKDQ LEAAAAGKDP EAVAGEFGRH SFYKMLGYFS
     LVGLLRVHSL LGDYHQAIKV LEPIEIHKKS QYSHIPSCQI STSYYVGFAY MMMRRYSDAI
     RTFSSILLYI QRTKQLYSAR SYQNDQINKQ TDQMYHLLAI CLVLHPQCID ESIQQVLREK
     NYHDNMYKMQ CGDLDVFRNF FVFACPKFVS PVPPPPDAPI EDYVKDALEH QINVFMDEVK
     QQQELPTIRS YLKLYTTLPI MKLASFMDRK PQDEVDEQKL ENLLTRLLCF KHKMKNVVWT
     KGSSGLEGKF QSGSELDFYI DKDMIHIADT KVSHRYGDFF IRKVMKFEDL NRRLHAIKG