ID   EIF3L_ASPCL             Reviewed;         476 AA.
AC   A1C690;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=ACLA_069410;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; DS027045; EAW13911.1; -; Genomic_DNA.
DR   RefSeq; XP_001275337.1; XM_001275336.1.
DR   AlphaFoldDB; A1C690; -.
DR   SMR; A1C690; -.
DR   STRING; 5057.CADACLAP00007015; -.
DR   EnsemblFungi; EAW13911; EAW13911; ACLA_069410.
DR   GeneID; 4707640; -.
DR   KEGG; act:ACLA_069410; -.
DR   VEuPathDB; FungiDB:ACLA_069410; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_2_0_1; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..476
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364255"
FT   DOMAIN          257..452
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   476 AA;  54753 MW;  97B2DAFF13C9DE3A CRC64;
     MSYEERVNAH PNLGDESDVE EEALVNDYRE QVNFDDGMSE LERTTSLGAA SQTQDLQAQL
     AAAATPLEYQ ATLETKFASY DNYCSLFHYI LNSEGPVELE VPSYYWAWDV IDEFIYQFES
     FCRYRNRVAR SGSNEEEAQL LRENPNTWGC YSVLNVLYSL IQRSQINEQL AAIKRGEDPL
     TVAGEYGSRP LYKMLGYFSI IGLLRVHCLL GDFSLALKTL DDIEMNKKAM FARVMAAHFT
     TYYYVGFSYM MMRRYGDAIR MFSHILVYVS RTKNFQKGGN SYDAIAKKND QMYALIAICV
     ALHPTRLDDT IHSALREKYG EQLIRLQHGG PEALPLFEEL FRSACPKFIS PTPPDFDNPA
     VNVDPVDHHT AIFMDEVKNT LYNPTIRSYL KLYTTMDLKK LAGFLEVEPE KLRSWLLVNK
     QRSRQVRWVE GGLLEGEPVN ANDLDYALEN DLIHVSETKA GRRLVDWYLR NLARVY