ID   EIF3L_CHAGB             Reviewed;         474 AA.
AC   Q2H9N4;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=CHGG_03070;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; CH408030; EAQ91135.1; -; Genomic_DNA.
DR   RefSeq; XP_001229586.1; XM_001229585.1.
DR   AlphaFoldDB; Q2H9N4; -.
DR   SMR; Q2H9N4; -.
DR   STRING; 38033.XP_001229586.1; -.
DR   EnsemblFungi; EAQ91135; EAQ91135; CHGG_03070.
DR   GeneID; 4388787; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_2_0_1; -.
DR   InParanoid; Q2H9N4; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..474
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364262"
FT   DOMAIN          255..449
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   474 AA;  54754 MW;  2308E16FEFC0C75F CRC64;
     MSYQTGMAPA RAMEDDSDVE EEALVADYRE QVQYSEGGME EMDQATLAQQ ADEIQSRLVQ
     ASQPLDFQAT LETKFASYDN YCALFHYILN SEGPVDLEPP TYYWAWDVID EFIYQFNTFC
     TYRARIARQA GNEEEAQILR DNPNTWGCYS VLNVLYSLIQ KSQITEQLAA MKRNEDPMAV
     AGPYGSKNLY RMLGYFSIIG LLRVHCLLGD FSLALKTLDD IELNKKAMFA RVMAAHFTTY
     YYVGFSYMMM RRYADAIRMF SHILIYVSRT KNFQKNTQYD SITKKNDQML ALIAICVAFH
     PTRLDDTIHT ALREKYGDQL LKLQRGGPDS LPVFEELFKS ACPKFMSPIP PDFDKPEANI
     DPIDHHLSVF MEEVKTNMWS PTVKSYLRLY TTMDLKKLAG FLDVKPEELR SWLLVSKQRT
     KQLRWTENGL LEGEPVNVSD LDYALQGDLI HISEAKMGRK LVDWYIRNLS RTYA