ID   EIF3L_CHICK             Reviewed;         564 AA.
AC   Q5F428;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   Name=EIF3L {ECO:0000255|HAMAP-Rule:MF_03011};
GN   Synonyms=EIF3EIP {ECO:0000255|HAMAP-Rule:MF_03011},
GN   EIF3S6IP {ECO:0000255|HAMAP-Rule:MF_03011}; ORFNames=RCJMB04_3l6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C,
CC       EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and
CC       EIF3M. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; AJ851472; CAH65106.1; -; mRNA.
DR   RefSeq; NP_001012553.1; NM_001012535.2.
DR   AlphaFoldDB; Q5F428; -.
DR   SMR; Q5F428; -.
DR   STRING; 9031.ENSGALP00000020064; -.
DR   PaxDb; Q5F428; -.
DR   Ensembl; ENSGALT00000020091; ENSGALP00000020064; ENSGALG00000012296.
DR   GeneID; 418033; -.
DR   KEGG; gga:418033; -.
DR   CTD; 51386; -.
DR   VEuPathDB; HostDB:geneid_418033; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   GeneTree; ENSGT00390000000411; -.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; Q5F428; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; Q5F428; -.
DR   Reactome; R-GGA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-GGA-72702; Ribosomal scanning and start codon recognition.
DR   PRO; PR:Q5F428; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000012296; Expressed in spleen and 13 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..564
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000297494"
FT   DOMAIN          331..537
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   564 AA;  66683 MW;  A543A9484025C9CE CRC64;
     MAYPGEDYDN DAAYDPYAYS NDYDMHTGDP KQDLAYERQY EQQTYQVIPE VIKNFIQYFH
     KTVSDLIDQK VYELQASRVS SDVIDQKVYE IQDIYENSWT KLTERFFKNT PWPEAEAIAP
     QVGNDAVFLI LYKELYYRHI YAKVSGGPTL EQRFESYYNY CNLFNYILNA DGPAPLELPN
     QWLWDIIDEF IYQFQSFSQY RCKTAKKSEE EIDFLRSNPK IWNVHSVLNV LHSLVDKSNI
     NRQLEVYTSG GDPESVAGEY GRHSLYKMLG YFSLVGLLRL HSLLGDYYQA IKVLENIELN
     KKSMYSRVPE CQVTTYYYVG FAYLMMRRYQ DAIRVFANIL LYIQRTKSMF QRTTYKYEMI
     NKQNEQMHAL LAIALTMYPM RIDESIHLQL REKYGDKMLR MQKGDAQVYE ELFSYACPKF
     LSPVVPNYDN VHPNYHKEPF LQQLKVFADE VQQQAQLSTI RSFLKLYTTM PVAKLAGFLD
     LTEQEFRIQL LVFKHKMKNL VWTSGISALD GEFQSASEVD FYIDKDMIHI ADTKVARRYG
     DFFIRQIHKF EELNRTLKKM GQRP