ID   EIF3L_CRYNB             Reviewed;         631 AA.
AC   P0CN57; Q55M47; Q5K8M2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   OrderedLocusNames=CNBI1650;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; AAEY01000044; EAL18904.1; -; Genomic_DNA.
DR   RefSeq; XP_773551.1; XM_768458.1.
DR   AlphaFoldDB; P0CN57; -.
DR   EnsemblFungi; EAL18904; EAL18904; CNBI1650.
DR   GeneID; 4938125; -.
DR   KEGG; cnb:CNBI1650; -.
DR   VEuPathDB; FungiDB:CNBI1650; -.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   Proteomes; UP000001435; Chromosome 9.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..631
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000410082"
FT   DOMAIN          335..526
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          571..631
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   631 AA;  70880 MW;  BA804265E21CC0B8 CRC64;
     MADPSAFYEP EEDELLSQLA IPIQNYQPLS EGDEYRRLQQ LEQHAYAQQT AMAQEQEMEQ
     LAVLELIPED VKRFLVMFHQ AILENDLPTI TSMYESGWNK LTQAHYLNNE WPEAELIAPL
     VGNDQVFLTL YRELYFRHVY ARLQPTIDDR FQSYENICEL FNYLLNSEGP VPLDLPIQWL
     WDMLDEFVYQ FTSFSHWRSS PKAKTEEELE MLAESPNIWS SYSVLNVLYS LVQKSQINEQ
     LKAERAGKSV EEVTEVAGEY GSKPLYKNLG YFSLICLLHV HVLLGDPTLA LQTMENVDLG
     NAAFLTRITA CHVTTYYHVG CAYMALGRWP DAIKTFVSVL IFFIRMKQYH TRSYQYGSIA
     KTCERMYALL AICTTLSPGP SDENIMTIVK EHYGDQLAIL QRGGPEALEA FKDLYLQACP
     KYLNVNPPPY EDASALEAWL ANPPADATQR HLELFLSDVQ AVQGVNGMRN LLKLYTSIDA
     AKLAAFSVSG EEEGEEEVLQ QLMVLKSASS TYGRGQAETT LLDGERKVTN NLDFTIDGTM
     VHVEETTSHR RYAGFFIRNA EHAQRALTSI KSAPLPVRKP ASSSAPAPAT TAAPISKSGE
     SAAPAPAEAP AAPEKKAGTW VPKSRQARIA A