ID   EIF3L_CULQU             Reviewed;         537 AA.
AC   B0WR18;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=CPIJ009242;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; DS232049; EDS33116.1; -; Genomic_DNA.
DR   RefSeq; XP_001851152.1; XM_001851100.1.
DR   AlphaFoldDB; B0WR18; -.
DR   SMR; B0WR18; -.
DR   STRING; 7176.CPIJ009242-PA; -.
DR   EnsemblMetazoa; XM_001851100.2; XP_001851152.1; LOC6041977.
DR   GeneID; 6041977; -.
DR   KEGG; cqu:CpipJ_CPIJ009242; -.
DR   VEuPathDB; VectorBase:CPIJ009242; -.
DR   VEuPathDB; VectorBase:CQUJHB007280; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; B0WR18; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; B0WR18; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..537
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364241"
FT   DOMAIN          300..512
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   537 AA;  63251 MW;  4921103AFE24B277 CRC64;
     MYSNDDYAEG GYEEYGYEMA ADDGYDRSFY PMHEDVKKFL VYFCSVIKGG VVYEIQNLYE
     NTFPKLSEQH FEKKAWPSED EVAHLVDNDN LFMILYKELY YRHLHARIQG GPSLEQRLNS
     FYNYCNFFNY ILPSKEPVQL ELPDIWLWEL IDEFVYQFQN FAQYRARLTD KSDEEMDMLL
     NNNSKVWNIL CILNVLHSLV SMSKIKDQLE AAAAGRDPEE VAGEFGRHSF YKMLGYFSLV
     GLLRVHSLLG DYHQAIKVLE PIELHKKSQY SHIPACQIST SYYVGFAYMM MRRYSDAIRT
     FSSILLYIQR TKQLYSARSY QNDQINKQTD QMYHLLAICL VLHPQCIDES IQQVLREKNY
     HDNMYKMQCG DLDTFRNFFV FACPKFVSPV PPPSDAPLDD YVKEALEHQT NVFMDEVRQQ
     QELPTIRSYL KLYTTLPLLK LASFMDHIPQ DEIGEQKIEN LLTHLLCFKH KMKNIVWTKG
     ASGLEGKFQS GSELDFYIDK DMIHIADTKV SHRYGDFFIR KILKFEDLNR RLHNLKG