ID   EIF3L_DANRE             Reviewed;         576 AA.
AC   Q7T2A5;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 6-interacting protein {ECO:0000255|HAMAP-Rule:MF_03011};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit E-interacting protein {ECO:0000255|HAMAP-Rule:MF_03011};
GN   Name=eif3l; Synonyms=eif3eip, eif3s6ip;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC       eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC       eif3m. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; BC054626; AAH54626.1; -; mRNA.
DR   RefSeq; NP_998293.1; NM_213128.1.
DR   AlphaFoldDB; Q7T2A5; -.
DR   SMR; Q7T2A5; -.
DR   STRING; 7955.ENSDARP00000090402; -.
DR   PaxDb; Q7T2A5; -.
DR   PRIDE; Q7T2A5; -.
DR   Ensembl; ENSDART00000161017; ENSDARP00000134724; ENSDARG00000101082.
DR   GeneID; 406402; -.
DR   KEGG; dre:406402; -.
DR   CTD; 406402; -.
DR   ZFIN; ZDB-GENE-040426-2138; eif3s6ip.
DR   eggNOG; KOG3677; Eukaryota.
DR   GeneTree; ENSGT00390000000411; -.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; Q7T2A5; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; Q7T2A5; -.
DR   TreeFam; TF101523; -.
DR   Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DRE-72649; Translation initiation complex formation.
DR   Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DRE-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-DRE-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   PRO; PR:Q7T2A5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000101082; Expressed in presomitic mesoderm and 28 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..576
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000297495"
FT   DOMAIN          330..536
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   576 AA;  67993 MW;  CC393326B16E9690 CRC64;
     MSYPAEEEDV NYDPYSYPND YDYHTGDPKA DLAYERQYEH QQTYHVIPEV IKNFLQYFHK
     TISDLIDQKV YELQANRVSS ESIEQKIYEI QDVYENSWNK LTDRFFKTSP WPEAEAIASL
     VGNDAVFLIL YKELYYRHIY AKVSGGPTLD QRFESYYNYC NLFNYILNAD GPAPLELPNQ
     WLWDIIDEFI YQFQSFSQYR CKTAKKSEEE IEFLRNNPKI WNVHSVLNVL HSLVDKSNIN
     RQLEVYTSGG DPESVAGEYG RHSLYKMLGY FSLVGLLRLH SLLGDYYQAI KVLENIELNK
     KSMYSRVPEC QITTYYYVGF AYLMMRRYQD AIRVFANILL YIQRTRNMFQ RTTYKYEMIN
     KQNEQMHGLL AIALTMYPMR IDESIHTQLR EKYGDKMLRM QKGDLQVFEE LFSFACPKFL
     SPVVPNYENV HPNYHKEPFQ QQLKVFAEEV QQQAQLSTIR SFLKLYTTMP VAKLAGFLDM
     SEQEFRIQLL VFKHKMKNLV WTSGISALDG EFQSASEVDF YIDKDMIHIA DTKVARRYGD
     FFIRQIHKFE ELNRTLKKMP LNTGASISSS STSRAT