ID   EIF3L_DROAN             Reviewed;         539 AA.
AC   B3M7W0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=GF25000;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; CH902618; EDV38833.1; -; Genomic_DNA.
DR   RefSeq; XP_001956027.1; XM_001955991.2.
DR   AlphaFoldDB; B3M7W0; -.
DR   SMR; B3M7W0; -.
DR   STRING; 7217.FBpp0128192; -.
DR   EnsemblMetazoa; FBtr0129700; FBpp0128192; FBgn0101992.
DR   GeneID; 6507626; -.
DR   KEGG; dan:6507626; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; B3M7W0; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; B3M7W0; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..539
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364242"
FT   DOMAIN          306..514
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   539 AA;  63053 MW;  C9D536C8F15D73A0 CRC64;
     MYGGDDYGNN AEYYDEYAHT GDPQLDMEYE RNYYASRMPE NVKYFLINFC QAIKEGTLYD
     IQNMYENTFP QISDHHFDKS AWPDEQEVGP IVDNDKVFLI LYKELYYRHI HARIPGGPKL
     DQRINSFFNY CDFFNLIISS QNPVMLELPD IWLWELVDEF VYQFQNFAQY RARLTDKSQD
     EIQQLCVNHS NVWSILCILN VLHSLVDISN IKKQLEAISQ GADPQTVAGD FGKLSFYKML
     GYFSLVGLLR VHSLLGDYYQ AIKVLEPIEI HKKSAYSHIP ACQISTSYYV GFAYMMMRRY
     ADAIRTFSDI LLYIQRTKQL YSTRSYQNDQ INKQAEQMYH LLAICLVLHP QCIDESIQQV
     LREKNYHDAM FKMQCGDLDV FKSFFVFACP RFVSPCPPAA DAPMEDYVKD PMEHQLMVFM
     DEVRQQKDLP TTRSYLKLYT TLPLAKLASF IDPNASDDDV SKLLIRLLCF KHKMRNLVWS
     KGPSGLEGAF KSGSELDFYI DDDMIHIADT KVSHRYGDFF VRKILKFNDL NRKLKKITI