ID   EIF3L_DROER             Reviewed;         539 AA.
AC   B3NH71;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=GG13851;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; CH954178; EDV51528.1; -; Genomic_DNA.
DR   RefSeq; XP_001972502.1; XM_001972466.2.
DR   AlphaFoldDB; B3NH71; -.
DR   SMR; B3NH71; -.
DR   STRING; 7220.FBpp0132397; -.
DR   EnsemblMetazoa; FBtr0133905; FBpp0132397; FBgn0106114.
DR   GeneID; 6544795; -.
DR   KEGG; der:6544795; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; B3NH71; -.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..539
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364243"
FT   DOMAIN          306..514
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   539 AA;  63197 MW;  DF672B1128356E7B CRC64;
     MYGGDEYANN SEYYDDYAHT GDPQLDMEYE RNYYAARMPD NVKYFLINFC QAIKEGNLYD
     IQNMYENTFP QISDHHFDKT AWPEEQEVAA IVDNDKVFLI LYKELYYRHI HARISGGPKL
     EQRINSFFNY CDFFNLIISA QNPVMLELPD IWLWELVDEF VYQFQNFAQY RARLTDKSQD
     EIQQLCVNHS NEWSILCILN VLHSLVDISN IKKQLEAISQ GVDPQTVAGD FGKLSFYKML
     GYFSLVGLLR VHSLLGDYYQ AIKVLEPIEI HKKSAYSHIP ACQISTSYYV GFAYMMMRRY
     ADAIRTFSDI LLYIQRTKQL YSTRSYQNDQ INKQAEQMYH LLAICLVLHP QCIDESIQQV
     LREKNYHDAM FKMQCGDLEV FKSFFVFACP RFVSPCPPAA DAPMEDYVKD PMEHQLLVFM
     DEVRQQKDLP TTRSYLKLYT TLPLTKLASF IDPNASEDDV SKLLIRLLCF KHKMRNLVWS
     KGPSGLEGTF KSGSELDFYI DDDMIHIADT KVSHRYGDFF VRKILKFNDL NRKLKNINI