ID   EIF3L_DROGR             Reviewed;         540 AA.
AC   B4IWN1;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=GH15308;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; CH916366; EDV96257.1; -; Genomic_DNA.
DR   RefSeq; XP_001983909.1; XM_001983873.1.
DR   AlphaFoldDB; B4IWN1; -.
DR   SMR; B4IWN1; -.
DR   STRING; 7222.FBpp0149214; -.
DR   EnsemblMetazoa; FBtr0150722; FBpp0149214; FBgn0122783.
DR   GeneID; 6556651; -.
DR   KEGG; dgr:6556651; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; B4IWN1; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; B4IWN1; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..540
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364244"
FT   DOMAIN          307..515
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   540 AA;  63305 MW;  D234B82FA1D573BD CRC64;
     MYGGEDFNNT QQDFYDDYAH TGDPALDLEY ERNYYANRMP ENVKYFLINF CQAIKEGNLY
     DIQNMYENTF PQISDHHFDK SAWPEEQEVG AIVDNDKVFL ILYKELYYRH IHARIPGGPK
     LDQRINSFFN YCDFFNLIIS AQNPVLLELP DIWLWELVDE FVYQFQNFAQ YRARLTDKSQ
     DEIQQLCVNH SNVWSILCIL NVLHSLVDIS NIKKQLEAIS QGIDPQTVAG DFGKLAFYKM
     LGYFSLVGLL RVHSLLGDYY QAIKVLEPIE IHKKSAYSHI PACQISTSYY VGFAYMMMRR
     YADAIRTFSD ILLYIQRTKQ LYSTRSYQND QINKQAEQMY HLLAICLVLH PQCIDESIQQ
     VLREKNYHDA MFKMQCGDLE VFKSFFVFAC PRFVSPCPPV ADAPLEDYVK DPMEHQLLVF
     MDEVRQQKDL PTTRSYLKLY TTLPLTKLAS FIDPNANEDD VSKLLIRLLC FKHKMRNLVW
     SKGPSGLEGT FKSGSELDFY IDDDMIHIAD TKVSHRYGDF FVRKIMKFND LNRKLKNINI