ID   EIF3L_DROPE             Reviewed;         541 AA.
AC   B4GR63;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=GL25016;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; CH479188; EDW40248.1; -; Genomic_DNA.
DR   RefSeq; XP_002021092.1; XM_002021056.1.
DR   AlphaFoldDB; B4GR63; -.
DR   SMR; B4GR63; -.
DR   STRING; 7234.FBpp0189123; -.
DR   EnsemblMetazoa; FBtr0190631; FBpp0189123; FBgn0162603.
DR   GeneID; 6596128; -.
DR   KEGG; dpe:6596128; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   OMA; AGWFIRN; -.
DR   PhylomeDB; B4GR63; -.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..541
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364247"
FT   DOMAIN          308..516
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   541 AA;  63300 MW;  CC23503D37EDC84A CRC64;
     MSKYSGEEFS NNGDFYDDFA HTGDPALDME YERNYYASRM PENVKYFLMN FCQAVKEGNL
     YDIQNMYENT FPQISDHHFD KSSWPEETEV GALVENDKVF MILYKELYYR HIHARIPGGP
     KLDQRINSFF NYCDFFNLII SAPNPVMLEL PDIWLWELVD EFVYQFQNFA QYRARLTDKS
     QEEIQQLCVN HSNVWSILCI LNVLHSLVDI SNIKKQLEAI SGGIDPNTVS GDFGKLSFYK
     MLGYFSLVDL LRVHSLLGDY YQAIKVLEPI EIHKKSAYSH IPACQISTSY YVGFAYMMMR
     RYADAIRTFS DILLYIQRTK QLYSTRSYQN DQINKQAEQM YHLLAICLVL HPQCIDESIQ
     QVLREKNYHD AMFKMQCGDL EVFKSFFVFA CPRFVSPCPP AADAPMEDYV KDPMEHQLQV
     FMDEVRQQKD LPTTRSYLKL YTTLPLAKLA SFIDPNANDD DVSKLLIRLL CFKHKMRNLV
     WSKGPSGLEG TFKSGSELDF YIDDDMIHIA DTKVSHRYGD FFVRKILKFN DLNRKLKNIN
     I