ID   EIF3L_DROPS             Reviewed;         541 AA.
AC   Q2M0S3;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=GA19025;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; CH379069; EAL30856.1; -; Genomic_DNA.
DR   RefSeq; XP_001353350.1; XM_001353314.2.
DR   AlphaFoldDB; Q2M0S3; -.
DR   SMR; Q2M0S3; -.
DR   STRING; 7237.FBpp0274629; -.
DR   EnsemblMetazoa; FBtr0276191; FBpp0274629; FBgn0079023.
DR   GeneID; 4813755; -.
DR   KEGG; dpo:Dpse_GA19025; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; Q2M0S3; -.
DR   OMA; AGWFIRN; -.
DR   PhylomeDB; Q2M0S3; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0079023; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..541
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364248"
FT   DOMAIN          308..516
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   541 AA;  63260 MW;  0E9BF2B6A75B8B6B CRC64;
     MSKYSGEEFS NNGDFYDDFA HTGDPALDME YERNYYASRM PENVKYFLMN FCQAVKEGNL
     YDIQNMYENT FPQISDHHFD KSSWPEETEV GALVENDKVF MILYKELYYR HIHARIPGGP
     KLDQRINSFF NYCDFFNLII SAPNPVMLEL PDIWLWELVD EFVYQFQNFA QYRARLTDKS
     QEEIQQLCVN HSNVWSILCI LNVLHSLVDI SNIKKQLEAI SGGIDPNTVS GDFGKLSFYK
     MLGYFSLVGL LRVHSLLGDY YQAIKVLEPI EIHKKSAYSH IPACQISTSY YVGFAYMMMR
     RYADAIRTFS DILLYIQRTK QLYSTRSYQN DQINKQAEQM YHLLAICLVL HPQCIDESIQ
     QVLREKNYHD AMFKMQCGDL EVFKSFFVFA CPRFVSPCPP AADAPMEDYV KDPMEHQLQV
     FMDEVRQQKD LPTTRSYLKL YTTLPLAKLA SFIDPNANDD DVSKLLIRLL CFKHKMRNLV
     WSKGPSGLEG TFKSGSELDF YIDDDMIHIA DTKVSHRYGD FFVRKIMKFN DLNRKLKNIN
     I