EIF3L_DROSE
ID EIF3L_DROSE Reviewed; 539 AA.
AC B4HFJ3;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN ORFNames=GM24677;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03011}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03011}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC Rule:MF_03011}.
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DR EMBL; CH480815; EDW41224.1; -; Genomic_DNA.
DR RefSeq; XP_002030238.1; XM_002030202.1.
DR AlphaFoldDB; B4HFJ3; -.
DR SMR; B4HFJ3; -.
DR STRING; 7238.B4HFJ3; -.
DR EnsemblMetazoa; FBtr0207662; FBpp0206154; FBgn0179540.
DR GeneID; 6605405; -.
DR KEGG; dse:6605405; -.
DR HOGENOM; CLU_029210_0_1_1; -.
DR OMA; AGWFIRN; -.
DR PhylomeDB; B4HFJ3; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03011; eIF3l; 1.
DR InterPro; IPR019382; eIF3l.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR13242; PTHR13242; 1.
DR Pfam; PF10255; Paf67; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..539
FT /note="Eukaryotic translation initiation factor 3 subunit
FT L"
FT /id="PRO_0000364249"
FT DOMAIN 306..514
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 539 AA; 63222 MW; 56282392899496CE CRC64;
MYGGDEYATN SEYYDDYAHT GDPQLDMEYE RNYYAARMPD NVKYFLINFC QAIKEGNLYD
IQNMYENTFP QISDHHFDKT AWPEEQEVAA IVDNDKVFLI LYKELYYRHI HARIPGGPKL
EQRINSFFNY CDFFNLIISA QNPVMLELPD IWLWELVDEF VYQFQNFAQY RARLTEKSQD
EIQQLCVNHS NEWSILCILN VLHSLVDISN IKKQLEAISQ GVDPQTVAGD FGKLSFYKML
GYFSLVGLLR VHSLLGDYYQ AIKVLEPIEI HKKSAYSHIP ACQISTSYYV GFAYMMMRRY
ADAIRTFSDI LLYIQRTKQL YSTRSYQNDQ INKQAEQMYH LLAICLVLHP QCIDESIQQV
LREKNYHDAM FKMQCGDLEV FKSFFVFACP RFVSPCPPAV DAPMDDYVKD PMEHQLLVFM
DEVRQQKDLP TTRSYLKLYT TLPLTKLASF IDPNASEDDV SKLLIRLLCF KHKMRNLVWS
KGPSGLEGTF KSGSELDFYI DDDMIHIADT KVSHRYGDFF VRKILKFNDL NRKLKNINI
