ID   EIF3L_DROVI             Reviewed;         538 AA.
AC   B4LEJ0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=GJ13043;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; CH940647; EDW69075.1; -; Genomic_DNA.
DR   RefSeq; XP_002046733.1; XM_002046697.2.
DR   AlphaFoldDB; B4LEJ0; -.
DR   SMR; B4LEJ0; -.
DR   STRING; 7244.FBpp0227460; -.
DR   EnsemblMetazoa; FBtr0228968; FBpp0227460; FBgn0200277.
DR   GeneID; 6623216; -.
DR   KEGG; dvi:6623216; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; B4LEJ0; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; B4LEJ0; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..538
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364251"
FT   DOMAIN          305..513
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   538 AA;  62989 MW;  C691A88FBE2CE943 CRC64;
     MYGGEEFGNS DFYDDYAHTG DPALDLEYER NFYANRMPEN VKYFLMNFCQ AIKEGNLYDI
     QNMYENTFPQ ISDHHFDKTA WPDEQEVGAI VDNDKVFLIL YKELYYRHIH ARIPGGPKLE
     QRINSFFNYC DFFNLIISAQ NPVMLELPDI WLWELVDEFV YQFQNFAQYR ARLTDKSQDE
     IQQLCVNHSN VWSILCILNV LHSLVDISNI KKQLEAISQG IDPQTVAGDF GKLAFYKMLG
     YFSLVGLLRV HSLLGDYYQA IKVLEPIEIH KKSAYSHIPA CQISTSYYVG FAYMMMRRYA
     DAIRTFSDIL LYIQRTKQLY STRSYQNDQI NKQAEQMYHL LAICLVLHPQ CIDESIQQVL
     REKNYHDAMF KMQCGDLEVF KSFFVFACPR FVSPCPPAAD APMEDYVKDP MEHQLLVFMD
     EVRQQKDLPT TRSYLKLYTT LPLTKLASFI DPNASEDDVS KLLIRLLCFK HKMRNLVWSK
     GPSGLEGTFK SGSELDFYID DDMIHIADTK VSHRYGDFFV RKIMKFNDLN RKLKNINI