ID   EIF3L_DROWI             Reviewed;         539 AA.
AC   B4MX71;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=GK20774;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; CH963876; EDW76904.1; -; Genomic_DNA.
DR   RefSeq; XP_002065918.1; XM_002065882.2.
DR   AlphaFoldDB; B4MX71; -.
DR   SMR; B4MX71; -.
DR   STRING; 7260.FBpp0249917; -.
DR   EnsemblMetazoa; FBtr0251425; FBpp0249917; FBgn0222770.
DR   GeneID; 6643137; -.
DR   KEGG; dwi:6643137; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; B4MX71; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; B4MX71; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..539
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364252"
FT   DOMAIN          306..514
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   539 AA;  63021 MW;  7F3809A5D2A1F849 CRC64;
     MYGGDEFSNN GDFYDDYAHT GDPQLDLEYE RSYYTSRMPD NVKYFLMNFC QAIKDGNLYD
     IQNMYENTFP QISDHHFDKT AWPEEQEVAS IVDNEKVFLI LYKELYFRHI HARIPGGPKL
     DQRINSFFNY CDFFNLIISA QNPVMLELPD IWLWELVDEF VYQFQNFAQY RARLTDKSQD
     EIQQLCVNHS NVWSILCILN VLHSLVDISN IKKQLEVISQ GVDPQTVAGD FGKLSFYKML
     GYFSLVGLLR VHSLLGDYYQ AIKVLEPIEI HKKSAYSHIP ACQISTSYYV GFAYMMMRRY
     ADAIRTFSDI LLYVQRTKQL YSTRSYQNDQ INKQAEQMYH LLAICLVLHP QCIDESIQQV
     LREKNYHDAM FKMQCGDLDV FKSFFIFACP RFVSPCPPAA DAPMEDYVKD PMEHQLLVFM
     DEVRQQKDLP TTRSYLKLYT TLPLAKLASF IDPNASEDDV SKLLIRLLCF KHKMRNLVWS
     KGPSGLEGSF KSGSELDFYI DDDMIHIADT KVSHRYGDFF VRKILKFNDL NRKLKGVNI