ID   EIF3L_MONBE             Reviewed;         512 AA.
AC   A9VCY6;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=39212;
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154;
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; CH991584; EDQ84584.1; -; Genomic_DNA.
DR   RefSeq; XP_001750611.1; XM_001750559.1.
DR   AlphaFoldDB; A9VCY6; -.
DR   SMR; A9VCY6; -.
DR   STRING; 81824.XP_001750611.1; -.
DR   PRIDE; A9VCY6; -.
DR   EnsemblProtists; EDQ84584; EDQ84584; MONBRDRAFT_39212.
DR   GeneID; 5895901; -.
DR   KEGG; mbr:MONBRDRAFT_39212; -.
DR   eggNOG; KOG3677; Eukaryota.
DR   InParanoid; A9VCY6; -.
DR   OMA; AGWFIRN; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..512
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364234"
FT   DOMAIN          291..477
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   512 AA;  59924 MW;  12BC730417FC950A CRC64;
     MEQETFEEQE ITVADINANV PQEVQNYLRS FNKAIQEKSL KEIEEHYEYK WRRTTDQYFK
     DSRWPEPVYI QAMFEQEGQE DSYFVSLYPE LYYRDVYYRS SNTNIEITVE DRHASYDHYI
     ELINMFVEPD APLDLELPNK WLWDMIDEFL YQFQDFVIFR SRVDDAKTES DYQEIAERPN
     AWNVTIVLNA LHSLILKSEI NEQLEAYRSG QNPTEMAGAF GKSSLYKMLG CFSLVGLVRL
     QCHLGDYRQA LQIMKNVDLD RRFIFSLVPA CNVSLHYHLG FCYLMLRRYQ DAFRLFESIL
     IQMASHRGPG HYDGGRKRDT IVCLLALAYS LLPQRLERSV EHLMNEKEGE NIRKIQSGEG
     ADEAINHLLL RGAPRFLCPF LADPQQPPEE DVLKAESERQ LELFKQEAKQ LILLGQIRSY
     LKLYTRMKLE KLAKFLELTV PQLRSMLHSF KHKMSQIVHT PGGEPLAGER QFTDSVDFYV
     DGDEICIATM TVKKSYGDDF LTASLKMVTS NR