ID   EIF3L_NEMVE             Reviewed;         525 AA.
AC   A7SDW5;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   ORFNames=v1g169424;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; DS469633; EDO38083.1; -; Genomic_DNA.
DR   RefSeq; XP_001630146.1; XM_001630096.1.
DR   AlphaFoldDB; A7SDW5; -.
DR   SMR; A7SDW5; -.
DR   STRING; 45351.EDO38083; -.
DR   EnsemblMetazoa; EDO38083; EDO38083; NEMVEDRAFT_v1g169424.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; A7SDW5; -.
DR   OMA; AGWFIRN; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; A7SDW5; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..525
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364235"
FT   DOMAIN          296..502
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   525 AA;  62225 MW;  FBAE44832E271B9E CRC64;
     MYTQADEYDG GDAGYEDDYS GYQGDGDDSV GSYNVPEEIK RFIHFFHQHV LEQNLYEIQS
     IYENGFNKLT DRYFNKTPWP EAEFIAPLVS GDQVFLILYK ELYYRHIYNK LKPTVEQRFE
     SYYNYCDLFN YILNTDEPVP LTLPNQWLWD IIDEFIYQFQ AFSQFRSKLQ NKPEDEIDVL
     RANSKIWNIH SVLNVLYSLV EKSRINYQLE MYNTNGNPDE VSGEFGIHPL YKMLGYFSLI
     GLLRLHSLLG DYFQAIKVLS NVELTRNTMY SRIPACQITT YYYVGFAYLM MRRYQDAIRC
     FSSVLLYIQR TKNMLQTKSY QYEEIMKKND QMYNLLAIAL TLCPQQLDEN VHSQLREKCT
     EKMQKLQKGD LQMFEECFSY SCPKFVSPVP PNFDAPPANY NREPFNLQLK VFMNEVAQQS
     MIPVIRSYLK LYTTMPIAKL AAFLDMDEAT FRNQLLCYKH KQRNLVWTKG TDGLDGEQQS
     SSEVDFYIDR DMIHIADTKV DRRYGEFFMR QIYKFDEMAR NLQAL