EIF3L_NEOFI
ID EIF3L_NEOFI Reviewed; 476 AA.
AC A1DGW6;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN ORFNames=NFIA_085780;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03011}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC Rule:MF_03011}.
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DR EMBL; DS027696; EAW18623.1; -; Genomic_DNA.
DR RefSeq; XP_001260520.1; XM_001260519.1.
DR AlphaFoldDB; A1DGW6; -.
DR SMR; A1DGW6; -.
DR STRING; 36630.CADNFIAP00006939; -.
DR EnsemblFungi; EAW18623; EAW18623; NFIA_085780.
DR GeneID; 4587078; -.
DR KEGG; nfi:NFIA_085780; -.
DR VEuPathDB; FungiDB:NFIA_085780; -.
DR eggNOG; KOG3677; Eukaryota.
DR HOGENOM; CLU_029210_2_0_1; -.
DR OMA; AGWFIRN; -.
DR OrthoDB; 393910at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03011; eIF3l; 1.
DR InterPro; IPR019382; eIF3l.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR13242; PTHR13242; 1.
DR Pfam; PF10255; Paf67; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..476
FT /note="Eukaryotic translation initiation factor 3 subunit
FT L"
FT /id="PRO_0000364267"
FT DOMAIN 257..452
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 476 AA; 54718 MW; DF37161C921EEA71 CRC64;
MSYEERVNAH PNLGDESDVE EEALVNDYRE QVNFDDGMSE LERTTSLGTG SQTQDLQAQL
AAAATPLEYQ ATLETKFASY DNYCSLFHYI LNSEGPVELE VPSYYWAWDV IDEFIYQFES
FCRYRNRVAR SGSNEEEAQL LRENPNTWGC YSVLNVLYSL IQKSQINEQL AAIKRGEDPL
AFAGEYGSRP LYKMLGYFSI IGLLRVHCLL GDFSLALKTL DDIEMNKKAM FARVMAAHFT
TYYYVGFSYM MMRRYGDAIR MFSHILVYVS RTKNFQKGGN SYDAIAKKND QMYALIAICV
ALHPTRLDDT IHSALREKYG EQLLRLQHGG PDALPLFEEL FRSACPKFIS PTPPDFDNPA
LNIDPVDHHT AIFMDEVKNT LYNPTIRSYL KLYTTMDLKK LAGFLEVQPE VLRSWLLVNK
QRSRQVRWVE GGLLEGEVVS ANDLDYALEN DLIHVSETKA GRRLVDWYLR NLARVY