EIF3L_USTMA
ID EIF3L_USTMA Reviewed; 668 AA.
AC Q4PF85; A0A0D1CYA5;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN ORFNames=UMAG_01228;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03011}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC Rule:MF_03011}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM003141; KIS71328.1; -; Genomic_DNA.
DR RefSeq; XP_011387162.1; XM_011388860.1.
DR AlphaFoldDB; Q4PF85; -.
DR SMR; Q4PF85; -.
DR STRING; 5270.UM01228P0; -.
DR EnsemblFungi; KIS71328; KIS71328; UMAG_01228.
DR GeneID; 23562318; -.
DR KEGG; uma:UMAG_01228; -.
DR VEuPathDB; FungiDB:UMAG_01228; -.
DR eggNOG; KOG3677; Eukaryota.
DR HOGENOM; CLU_029210_0_1_1; -.
DR InParanoid; Q4PF85; -.
DR OMA; ACHVTAY; -.
DR OrthoDB; 393910at2759; -.
DR Proteomes; UP000000561; Chromosome 2.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR HAMAP; MF_03011; eIF3l; 1.
DR InterPro; IPR019382; eIF3l.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR13242; PTHR13242; 1.
DR Pfam; PF10255; Paf67; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..668
FT /note="Eukaryotic translation initiation factor 3 subunit
FT L"
FT /id="PRO_0000364270"
FT DOMAIN 358..552
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 75128 MW; 731AB36B6491F580 CRC64;
MVADASQQGQ SNGAAFNQQQ QYQQQQQRQL FGGEEEFGDE EELGDDVDLV VGDYSAAFAG
EAGAEVDEAQ AAALAAAHAQ AQQQAQAAAL AAVPDQIRKY VVLFNQAVQI NNVQDISNAY
EGTWNRLTDK FYARSEWPEA ETIAPLVNDD QKFLTLYREL WYRHVYSRLS PDGEDRFHSY
DNYCDFFNFV LNSDGPVQLE LPAQWLWDII DEFIYQFQSF SQWRNKVSNK SEDEIALLQD
GGVWSSYSVL NVLYSLIQKS RITEQLVAAS KGEDPDEVAG EFGSKPLYRM LGYFSIIGLL
RVHVLLGDYT LALKMLDHIE LNKKSGLINR VTACHVTAYY YVGFAYLMLR RYPDCIKSFT
HILVFIMRLR QYHTRSYQYD QINKTADRMY ALLSMACALC PTRLDENIQT QMRDKYGDQF
SKMTRPGAEG LAAFEELFIY ACPKFITANS PAYHDEEALV EYKQKAVFPD PTQHQLRVFL
SDVKTQLSNA NVRSFLRLYT TLGTDKLASF LEIDEEELVE MMMVMKNSTR SLKWSSGSLL
HGQVVNTSDL DFVIDTDMVH IAESRVGRRY GDWFLRNGTR MHDVLNNIQA KPLPIVSKQV
QDEAAAAAAE AKDAKDKKVK NAWAAGVKAG PPAFSQRSGG AGRSSVNKSA PAPAGAWGSS
KPQPSVTA
