ID   EIF3L_XENLA             Reviewed;         562 AA.
AC   Q8AVJ0;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 6-interacting protein {ECO:0000255|HAMAP-Rule:MF_03011};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit E-interacting protein {ECO:0000255|HAMAP-Rule:MF_03011};
GN   Name=eif3l; Synonyms=eif3eip, eif3s6ip;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC       eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC       eif3m. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC042253; AAH42253.1; -; mRNA.
DR   RefSeq; NP_001080345.1; NM_001086876.1.
DR   AlphaFoldDB; Q8AVJ0; -.
DR   SMR; Q8AVJ0; -.
DR   BioGRID; 98279; 2.
DR   IntAct; Q8AVJ0; 1.
DR   DNASU; 380037; -.
DR   GeneID; 380037; -.
DR   KEGG; xla:380037; -.
DR   CTD; 380037; -.
DR   Xenbase; XB-GENE-493737; eif3l.L.
DR   OMA; ACHVTAY; -.
DR   OrthoDB; 393910at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 380037; Expressed in lung and 19 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..562
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000297496"
FT   DOMAIN          329..535
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   562 AA;  66523 MW;  7C2921172F5C1F20 CRC64;
     MSHAKEDYDS SYDPYSYQAD YDGHTGDPKQ DLAYERQYEQ QTYQVIPEVI KNFIQYFHKT
     VSDLIDQKVY ELQASRVSSD LIDQKVYEIQ DIYENSWAKL TERFFKNAPW PEAEAIAPQV
     GNDAVFLILY KELYYRHIYA KVTGGPTLEQ RFESYYNYCN LFNYILNADG PAPLELPNQW
     LWDIIDEFIY QFQSFSQYRC KTAKKSEEEI EFLRSNPKIW NVHSVLNVLH SLVDKSNINR
     QLEVYTSGGD PESVAGEYGR HSLYKMLGYF SLVGLLRLHS LLGDYYQAIK VLENIELNKK
     SMYSRVPECQ VTTYYYVGFA YLMMRRYQDS IRVFANILLY IQRTKSMFQR TTYKYEMINK
     QNEQMHALLS IALTMYPMRI DESIHTQLRE KYGDKMLRMQ KGDAQIYEEL FNYACPKFLS
     PVVPNYDNVN PNYHKEPYLQ QLKVFLDEVQ QQAQLSTIRS FLKLYTTMPV AKLAGFLDLP
     EQEFRIQLLV FKHKMKNLVW TSGISALEGE FQSASEVDFY IDKDMIHIAD TKVARRYGDF
     FIRQIHKFEE LNKTLKKMSQ KP