ID   EIF3L_XENTR             Reviewed;         562 AA.
AC   Q6P878;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 6-interacting protein {ECO:0000255|HAMAP-Rule:MF_03011};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit E-interacting protein {ECO:0000255|HAMAP-Rule:MF_03011};
GN   Name=eif3l; Synonyms=eif3eip, eif3s6ip;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC       eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC       eif3m. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
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DR   EMBL; BC061351; AAH61351.1; -; mRNA.
DR   RefSeq; NP_988980.1; NM_203649.1.
DR   AlphaFoldDB; Q6P878; -.
DR   SMR; Q6P878; -.
DR   STRING; 8364.ENSXETP00000056993; -.
DR   PaxDb; Q6P878; -.
DR   GeneID; 394577; -.
DR   KEGG; xtr:394577; -.
DR   CTD; 51386; -.
DR   Xenbase; XB-GENE-493733; eif3l.
DR   eggNOG; KOG3677; Eukaryota.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; Q6P878; -.
DR   OMA; ACHVTAY; -.
DR   OrthoDB; 393910at2759; -.
DR   PhylomeDB; Q6P878; -.
DR   TreeFam; TF101523; -.
DR   Reactome; R-XTR-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-XTR-72649; Translation initiation complex formation.
DR   Reactome; R-XTR-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-XTR-72702; Ribosomal scanning and start codon recognition.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027274; Expressed in skeletal muscle tissue and 24 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..562
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000297497"
FT   DOMAIN          329..535
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   562 AA;  66613 MW;  C0393E711095E3D1 CRC64;
     MSYANEEFEG SYDPYNYQAD YDMHTGDPKQ DLAYERQYEQ QTYQVIPEVI KNFIQYFHKT
     VSDLIDQKVY ELQASRVSSD VIDQKVYEIQ DIYENSWTKL TERFFKNSPW PEAEAIAPQV
     GNDAVFLILY KELYYRHIYA KVSGGPTLEQ RFESYYNYCN LFNYILNADG PAPLELPNQW
     LWDIIDEFIY QFQSFSQYRC KTAKKSEEEI EFLRSNPKIW NVHSVLNVLH SLVDKSNINR
     QLEVYTSGGD PESVAGEYGR HSLYKMLGYF SLVGLLRLHS LLGDYYQAIK VLENIELNKK
     SMYSRVPECQ VTTYYYVGFA YLMMRRYQDA IRVFANILLY IQRTKSMFQR TTYKYEMINK
     QNEQMHGLLA IALTMYPMRI DESIHTQLRE KYGDKMLRMQ KGDAQIYEEL FNYACPKFLS
     PVVPNYDNVH PNYHKEPYLQ QLKVFLDEVQ QQAQLSTIRS FLKLYTTMPV AKLAGFLDLP
     EQEFRIQLLV FKHKMKNLVW TSGISALEGE FQSASEVDFY IDKDMIHIAD TKVARRYGDF
     FIRQIHKFEE LNKTLKKMSQ KP