ID   EIF3L_YARLI             Reviewed;         520 AA.
AC   Q6CAE9;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011};
DE            Short=eIF3l {ECO:0000255|HAMAP-Rule:MF_03011};
GN   OrderedLocusNames=YALI0D03399g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit L family. {ECO:0000255|HAMAP-
CC       Rule:MF_03011}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382130; CAG80551.1; -; Genomic_DNA.
DR   RefSeq; XP_502363.1; XM_502363.1.
DR   AlphaFoldDB; Q6CAE9; -.
DR   SMR; Q6CAE9; -.
DR   STRING; 4952.CAG80551; -.
DR   EnsemblFungi; CAG80551; CAG80551; YALI0_D03399g.
DR   GeneID; 2910573; -.
DR   KEGG; yli:YALI0D03399g; -.
DR   VEuPathDB; FungiDB:YALI0_D03399g; -.
DR   HOGENOM; CLU_029210_0_1_1; -.
DR   InParanoid; Q6CAE9; -.
DR   OMA; AGWFIRN; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   HAMAP; MF_03011; eIF3l; 1.
DR   InterPro; IPR019382; eIF3l.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13242; PTHR13242; 1.
DR   Pfam; PF10255; Paf67; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..520
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   L"
FT                   /id="PRO_0000364271"
FT   DOMAIN          278..478
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   520 AA;  59618 MW;  AB3FAA4CA65F4129 CRC64;
     MDSDEEFIDN SLAVGDIVYD EAQIAQQQQE YAAQLKLAST AIPTVVKDFI QYFHRCLSDN
     SVYELHGCYE NSFGKLTDKF YKNSHWPHPV AQVAPLVKND PVFLYFYSEL YYRHLYAKLT
     PTPLERFESY SNYCNLFNYI LNSDGPVDLE LPTSWAWGIV DEFIYQYNSY WMTKEAHNSD
     GVAPDTWGTY SVLNVLYSLS EKTKIREQLR AIKAGLDPMD VAGPYGSRPL YKMLGYFCVI
     GLLRVHTLLG DFTLALKTME SIELTKKALF ARVAPAHFAT YYYVGICYVM TRRYADAIRC
     FSHVLTYMAR TKNVQGPRYD AKRSEQMYAL LAICVVLSPA RLDDSIHVAL RDRYGDQMAA
     MQRGDLKLFE ELFTFAAPKF IQPGDVHGGD PLKHHLKIFM VDVTNTLSTA NLKSYLNLYA
     TMDLGKLASF LDTDAEDLRS QLVTLKMKNR QLRWTEGELA DGTYQHCSEL DIALENDLIH
     VAEAKGGRKF ADWFIRNTVK NYSVQDYIVN GDKKDKEKKN