EIF3M_CAEBR
ID EIF3M_CAEBR Reviewed; 390 AA.
AC A8WQY8;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=COP9/Signalosome and eIF3 complex-shared subunit 1 {ECO:0000255|HAMAP-Rule:MF_03012};
DE AltName: Full=COP9 signalosome complex subunit 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE Short=Signalosome subunit 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
GN Name=cif-1 {ECO:0000255|HAMAP-Rule:MF_03012};
GN Synonyms=csn-7 {ECO:0000255|HAMAP-Rule:MF_03012},
GN eif-3.M {ECO:0000255|HAMAP-Rule:MF_03012}; ORFNames=CBG01738;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC Component of the COP9 signalosome complex (CSN), a complex involved in
CC various cellular and developmental processes. The CSN complex is an
CC essential regulator of the ubiquitin (Ubl) conjugation pathway by
CC mediating the deneddylation of the cullin subunits of the SCF-type E3
CC ligase complexes, leading to decrease the Ubl ligase activity of SCF.
CC The CSN complex plays an essential role in embryogenesis and oogenesis
CC and is required to regulate microtubule stability in the early embryo.
CC Mediates mei-1 targeting for degradation at the meiosis to mitosis
CC transition via deneddylation of cul-3. {ECO:0000255|HAMAP-
CC Rule:MF_03012}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. Within the eIF-3 complex, interacts directly with eif-
CC 3.F. Component of the CSN complex, composed of csn-1, csn-2, csn-3,
CC csn-4, csn-5, csn-6 and csn-7. Within the CSN complex, interacts
CC directly with csn-1 and csn-4. {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC Rule:MF_03012}.
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DR EMBL; HE601298; CAP22896.1; -; Genomic_DNA.
DR RefSeq; XP_002634171.1; XM_002634125.1.
DR AlphaFoldDB; A8WQY8; -.
DR SMR; A8WQY8; -.
DR STRING; 6238.CBG01738; -.
DR EnsemblMetazoa; CBG01738.1; CBG01738.1; WBGene00024927.
DR EnsemblMetazoa; CBG01738.2; CBG01738.2; WBGene00024927.
DR GeneID; 8576166; -.
DR KEGG; cbr:CBG_01738; -.
DR CTD; 8576166; -.
DR WormBase; CBG01738; CBP14243; WBGene00024927; Cbr-cif-1.
DR eggNOG; KOG2753; Eukaryota.
DR HOGENOM; CLU_035254_1_0_1; -.
DR InParanoid; A8WQY8; -.
DR OMA; REDAQRC; -.
DR OrthoDB; 679771at2759; -.
DR Proteomes; UP000008549; Chromosome IV.
DR GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-UniRule.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0060184; P:cell cycle switching; IEA:EnsemblMetazoa.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:1904667; P:negative regulation of ubiquitin protein ligase activity; IEA:EnsemblMetazoa.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0000338; P:protein deneddylation; IEA:UniProtKB-UniRule.
DR GO; GO:1905879; P:regulation of oogenesis; IEA:EnsemblMetazoa.
DR HAMAP; MF_03012; eIF3m; 1.
DR InterPro; IPR045237; COPS7/eIF3m.
DR InterPro; IPR027528; eIF3m.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR15350; PTHR15350; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Developmental protein; Differentiation; Initiation factor;
KW Oogenesis; Protein biosynthesis; Reference proteome; Signalosome.
FT CHAIN 1..390
FT /note="COP9/Signalosome and eIF3 complex-shared subunit 1"
FT /id="PRO_0000366008"
FT DOMAIN 188..351
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 390 AA; 44102 MW; 8F9753C965AF114B CRC64;
MADTRELPVF AYIDDIKQLQ ELRQYLNKHE SVKLDPTGPA ETAKNLVEIC STLHVLPLWS
QDVDLVLNSI SSLIVVVPGE KCEPVVDAFI KNVSPKFYKG IGWGSHAGIA VRVLSNLYKG
YSNFHTVQEK IFMALVDMCA EARLIGELEC NLETLHDRFN TWQTPVEGQR EILRAVHRAL
LVDQRADQAA KVMTALLGTY TEKDAATARD DAMECVRTAV VDPKSFSFDH LERLSAVKAL
KSSDPLMFTA LELFISGTLK DYQQFVAKNP KFVTDYLKVD EVILLKKIRL LTLMSLAEEK
NEIKLDELAK QLDIHADETL EEFVIDAIQV NAISGKINEM ANTLIVSSYQ HRRFGSDQWV
LLEKRLKVLI ANLKQTHNNV HEVNQRIEAL
