EIF3M_CAEEL
ID EIF3M_CAEEL Reviewed; 390 AA.
AC Q94261;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=COP9/Signalosome and eIF3 complex-shared subunit 1 {ECO:0000255|HAMAP-Rule:MF_03012};
DE AltName: Full=COP9 signalosome complex subunit 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE Short=Signalosome subunit 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
GN Name=cif-1 {ECO:0000255|HAMAP-Rule:MF_03012};
GN Synonyms=csn-7 {ECO:0000255|HAMAP-Rule:MF_03012},
GN eif-3.M {ECO:0000255|HAMAP-Rule:MF_03012}; ORFNames=K08F11.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP PROTEIN SEQUENCE OF 242-260, IDENTIFICATION IN THE CSN COMPLEX AND IN THE
RP EIF-3 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, AND
RP INTERACTION WITH CSN-1; CSN-4 AND EIF-3.F.
RX PubMed=17403899; DOI=10.1128/mcb.01724-06;
RA Luke-Glaser S., Roy M., Larsen B., Le Bihan T., Metalnikov P., Tyers M.,
RA Peter M., Pintard L.;
RT "CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation
RT factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans
RT embryo.";
RL Mol. Cell. Biol. 27:4526-4540(2007).
RN [3]
RP IDENTIFICATION.
RX PubMed=12781129; DOI=10.1016/s0960-9822(03)00336-1;
RA Pintard L., Kurz T., Glaser S., Willis J.H., Peter M., Bowerman B.;
RT "Neddylation and deneddylation of CUL-3 is required to target MEI-1/katanin
RT for degradation at the meiosis-to-mitosis transition in C. elegans.";
RL Curr. Biol. 13:911-921(2003).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation
CC (Potential). Component of the COP9 signalosome complex (CSN), a complex
CC involved in various cellular and developmental processes
CC (PubMed:17403899). The CSN complex is an essential regulator of the
CC ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of
CC the cullin subunits of the SCF-type E3 ligase complexes, leading to
CC decrease the Ubl ligase activity of SCF (PubMed:17403899). The CSN
CC complex plays an essential role in embryogenesis and oogenesis and is
CC required to regulate microtubule stability in the early embryo.
CC Mediates mei-1 targeting for degradation at the meiosis to mitosis
CC transition via deneddylation of cul-3 (PubMed:17403899).
CC {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:17403899}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. Within the eIF-3 complex, interacts directly with eif-
CC 3.F. Component of the CSN complex, composed of csn-1, csn-2, csn-3,
CC csn-4, csn-5, csn-6 and csn-7. Within the CSN complex, interacts
CC directly with csn-1 and csn-4. {ECO:0000255|HAMAP-Rule:MF_03012,
CC ECO:0000269|PubMed:17403899}.
CC -!- INTERACTION:
CC Q94261; Q9N359: csn-4; NbExp=3; IntAct=EBI-318834, EBI-331347;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC Rule:MF_03012}.
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DR EMBL; FO081041; CCD68723.1; -; Genomic_DNA.
DR PIR; T30020; T30020.
DR RefSeq; NP_500618.1; NM_068217.5.
DR AlphaFoldDB; Q94261; -.
DR SMR; Q94261; -.
DR BioGRID; 42365; 30.
DR ComplexPortal; CPX-3386; COP9 signalosome complex.
DR DIP; DIP-27147N; -.
DR IntAct; Q94261; 8.
DR STRING; 6239.K08F11.3.1; -.
DR EPD; Q94261; -.
DR PaxDb; Q94261; -.
DR PeptideAtlas; Q94261; -.
DR EnsemblMetazoa; K08F11.3.1; K08F11.3.1; WBGene00019543.
DR EnsemblMetazoa; K08F11.3.2; K08F11.3.2; WBGene00019543.
DR GeneID; 177236; -.
DR KEGG; cel:CELE_K08F11.3; -.
DR UCSC; K08F11.3.1; c. elegans.
DR CTD; 177236; -.
DR WormBase; K08F11.3; CE11954; WBGene00019543; cif-1.
DR eggNOG; KOG2753; Eukaryota.
DR GeneTree; ENSGT00390000004456; -.
DR HOGENOM; CLU_035254_1_0_1; -.
DR InParanoid; Q94261; -.
DR OMA; REDAQRC; -.
DR OrthoDB; 679771at2759; -.
DR PhylomeDB; Q94261; -.
DR Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR PRO; PR:Q94261; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00019543; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0008180; C:COP9 signalosome; IPI:ComplexPortal.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0060184; P:cell cycle switching; IMP:ComplexPortal.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:1904667; P:negative regulation of ubiquitin protein ligase activity; IMP:ComplexPortal.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0000338; P:protein deneddylation; IC:ComplexPortal.
DR GO; GO:1905879; P:regulation of oogenesis; IMP:ComplexPortal.
DR HAMAP; MF_03012; eIF3m; 1.
DR InterPro; IPR045237; COPS7/eIF3m.
DR InterPro; IPR027528; eIF3m.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR15350; PTHR15350; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; Differentiation;
KW Direct protein sequencing; Initiation factor; Oogenesis;
KW Protein biosynthesis; Reference proteome; Signalosome.
FT CHAIN 1..390
FT /note="COP9/Signalosome and eIF3 complex-shared subunit 1"
FT /id="PRO_0000121001"
FT DOMAIN 188..351
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 390 AA; 44084 MW; D32E1A5B53A42C6F CRC64;
MADTRELPVF AYIDDVKQLQ ELRQYLNKHD SVKLDPNGPS ETAQNMIEIC STLNVLPSWS
QDVDLVLNSI SSLIVVVPGE KCEPVVDSFI KNVAPQFYKG TGWASHAGIA VRVLSNLYKG
YSNFHTVQEK IFKALVDMCA EARLIGELEC NLETLQDRFN TWKTPVEGQR EILRAVHRAL
LVDQRVDQAA KVMTALLGTY TEKDAAAARD DAMECVRTAV VDPKSFSFDH LERLSAVKAL
KTSDPLMFTA LELFISGTLK DYKEFVAKNP KFVTEHLKVD ETILLKKIRL LTLMSLAEEK
NEISLDELAK QLDILADETL EEFVIDAIQV NAISGKINEM ARTLIVSSYQ HRRFGTEQWV
LLEKRLKVLI ANLKQTHNNV HEVNQRIEAL
