ID   EIF3M_CHAGB             Reviewed;         426 AA.
AC   Q2HE94;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
GN   ORFNames=CHGG_01460;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC       Rule:MF_03012}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAQ93225.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CH408029; EAQ93225.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001220681.1; XM_001220680.1.
DR   AlphaFoldDB; Q2HE94; -.
DR   SMR; Q2HE94; -.
DR   STRING; 38033.XP_001220681.1; -.
DR   EnsemblFungi; EAQ93225; EAQ93225; CHGG_01460.
DR   GeneID; 4387055; -.
DR   eggNOG; KOG2753; Eukaryota.
DR   HOGENOM; CLU_035254_0_0_1; -.
DR   InParanoid; Q2HE94; -.
DR   OrthoDB; 679771at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03012; eIF3m; 1.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR027528; eIF3m.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..426
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   M"
FT                   /id="PRO_0000366016"
FT   DOMAIN          179..350
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          385..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..399
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   426 AA;  48756 MW;  6A4529E086A725C6 CRC64;
     MAAPQLIFVD GTFAELAQEM AEYVQIGEQV KPYLAKEQNE EALQAIIEAS HVLNSIPEKE
     FTGAYNLLIH LVLQSKDPLK YLPPLCGNLQ KPITSSPAHG FTLAANALST VFNLLEPDNP
     TRFNVLLQIT RFIRQHGQYD LLKPRLENLE GWFNLWNTSD EDQRRLYVEV SDTAAEAGDD
     EDSYRYLIKA IATFGREDQD EITSEEAQKL SLKAVRLAIS HPARFDFQDL RILPSVQALG
     DSHPVYSQLL DIFIEQDLED YNDFKDEHEG WVEKEKLDNE KLQRKMRLLT FASLAASTPN
     REIPYANIAK ALQIPSEEVE MWTIDVVRAK LVEGRLSQQQ KVFLVHRTTY RVFGEKQWRE
     LATRVDQYKS IVDQLLVFLR KGQADVEGQR EREQQELERK LAGAGMGGGP GGDRRRQQKP
     RTDEDD