ID   EIF3M_CULQU             Reviewed;         386 AA.
AC   B0WTN3;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
GN   ORFNames=CPIJ010525;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC       Rule:MF_03012}.
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DR   EMBL; DS232090; EDS34491.1; -; Genomic_DNA.
DR   RefSeq; XP_001855135.1; XM_001855089.1.
DR   AlphaFoldDB; B0WTN3; -.
DR   SMR; B0WTN3; -.
DR   STRING; 7176.CPIJ010525-PA; -.
DR   EnsemblMetazoa; XM_001855089.2; XP_001855135.1; LOC6043043.
DR   GeneID; 6043043; -.
DR   KEGG; cqu:CpipJ_CPIJ010525; -.
DR   VEuPathDB; VectorBase:CPIJ010525; -.
DR   VEuPathDB; VectorBase:CQUJHB012855; -.
DR   eggNOG; KOG2753; Eukaryota.
DR   HOGENOM; CLU_035254_1_0_1; -.
DR   InParanoid; B0WTN3; -.
DR   OMA; REDAQRC; -.
DR   OrthoDB; 679771at2759; -.
DR   PhylomeDB; B0WTN3; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03012; eIF3m; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR027528; eIF3m.
DR   InterPro; IPR040750; eIF3m_C_helix.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   Pfam; PF18005; eIF3m_C_helix; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..386
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   M"
FT                   /id="PRO_0000365997"
FT   DOMAIN          181..343
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   386 AA;  44329 MW;  8A0D3A6BE2AD149D CRC64;
     MQVAAIFIDA EIEDQAQELR KFFKKLGAEI SEDKSSKGIE DDLHKIIGVC DVCFKDPSLH
     TVEEIDAVLN SVVSIIVSIP LERGENLILA FCEKMTKAPD QKLAQVCLQS LWRLFSNLEL
     TSPLRYHVYY HLVQVAKQVD QVKEVFTGVE QLKNQFTQCP PSNEQMQKLY RLLHDVLKDT
     NSELASKVMI ELLGTYTAEN ASYAREDAMK CIVTALADPN TFLLDPLLSL KPVRFLEGEL
     IHDLLSVFVS EKLPAYLQFY QNHKEFVNSQ GLNHEQNIKK MRLLSFMQLA ESNPEMTFAQ
     LQDELQIGEN DVEPFIIEVL KTKLVRARMD QKARKVHISS TMHRTFGRPQ WQQLRDLLHA
     WKANLTLVQE NMKSVAEAQI ELTRKQ