ID   EIF3M_DROER             Reviewed;         387 AA.
AC   B3NRC6;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
DE   AltName: Full=Transport and Golgi organization protein 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=Tango-7 {ECO:0000255|HAMAP-Rule:MF_03012};
GN   Name=Tango7 {ECO:0000255|HAMAP-Rule:MF_03012}; ORFNames=GG22442;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC       Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC       Rule:MF_03012}.
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DR   EMBL; CH954179; EDV56078.1; -; Genomic_DNA.
DR   RefSeq; XP_001975678.1; XM_001975642.2.
DR   AlphaFoldDB; B3NRC6; -.
DR   SMR; B3NRC6; -.
DR   STRING; 7220.FBpp0140988; -.
DR   EnsemblMetazoa; FBtr0142496; FBpp0140988; FBgn0114614.
DR   GeneID; 6549368; -.
DR   KEGG; der:6549368; -.
DR   eggNOG; KOG2753; Eukaryota.
DR   HOGENOM; CLU_035254_1_0_1; -.
DR   OMA; REDAQRC; -.
DR   OrthoDB; 679771at2759; -.
DR   PhylomeDB; B3NRC6; -.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0070865; C:investment cone; IEA:EnsemblMetazoa.
DR   GO; GO:0089720; F:caspase binding; IEA:EnsemblMetazoa.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IEA:EnsemblMetazoa.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0007030; P:Golgi organization; IEA:EnsemblMetazoa.
DR   GO; GO:2001272; P:positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IEA:EnsemblMetazoa.
DR   GO; GO:0009306; P:protein secretion; IEA:EnsemblMetazoa.
DR   GO; GO:0007291; P:sperm individualization; IEA:EnsemblMetazoa.
DR   HAMAP; MF_03012; eIF3m; 1.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR027528; eIF3m.
DR   InterPro; IPR040750; eIF3m_C_helix.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   Pfam; PF18005; eIF3m_C_helix; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Golgi apparatus; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..387
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   M"
FT                   /id="PRO_0000365999"
FT   DOMAIN          181..340
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   387 AA;  44108 MW;  689CF5AB572F9009 CRC64;
     MTSHPVFIDL SLDEQVQELR KYFKKLGAEI SSEKSNKGVE DDLHKIIGVC DVCFKDGEPS
     QIDGILNSIV SIMITIPLDR GENIVLAYCE KMTKAPNLPL GKVCLQSLWR LFNNLDTASP
     LRYHVYYHLV QVAKQCEQVL EVFTGVDQLK SQFANCPPSS EQMQKLYRLL HDVTKDTNLE
     LSSKVMIELL GTYTADNACV AREDAMKCIV TALADPNTFL LDPLLALKPV RFLEGDLIHD
     LLSIFVSEKL PAYVQFYEDH REFVNSQGLN HEQNMKKMRL LTFMQLAESS PEMTFETLTK
     ELQINEDEVE PFVIEVLKTK LVRARLDQAN HKVHITSTMH RTFGAPQWEQ LRDLLQAWKE
     NLSTVREGLT SVSSAQLDLA RSQKLIH