ID   EIF3M_DROGR             Reviewed;         387 AA.
AC   B4JW83;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
DE   AltName: Full=Transport and Golgi organization protein 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=Tango-7 {ECO:0000255|HAMAP-Rule:MF_03012};
GN   Name=Tango7 {ECO:0000255|HAMAP-Rule:MF_03012}; ORFNames=GH22989;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC       Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC       Rule:MF_03012}.
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DR   EMBL; CH916375; EDV98221.1; -; Genomic_DNA.
DR   RefSeq; XP_001995149.1; XM_001995113.1.
DR   AlphaFoldDB; B4JW83; -.
DR   SMR; B4JW83; -.
DR   STRING; 7222.FBpp0156895; -.
DR   EnsemblMetazoa; FBtr0158403; FBpp0156895; FBgn0130446.
DR   GeneID; 6569133; -.
DR   KEGG; dgr:6569133; -.
DR   eggNOG; KOG2753; Eukaryota.
DR   HOGENOM; CLU_035254_1_0_1; -.
DR   InParanoid; B4JW83; -.
DR   OMA; REDAQRC; -.
DR   OrthoDB; 679771at2759; -.
DR   PhylomeDB; B4JW83; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03012; eIF3m; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR027528; eIF3m.
DR   InterPro; IPR040750; eIF3m_C_helix.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   Pfam; PF18005; eIF3m_C_helix; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Golgi apparatus; Initiation factor; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..387
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   M"
FT                   /id="PRO_0000366000"
FT   DOMAIN          181..340
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   387 AA;  44117 MW;  D76056C609507B2E CRC64;
     MASHPVFIDL SLDEQVQELR KFFKKLGAEI SSEKSNKGVE DDLHKIIGVC EVCFKDGEPA
     QIDGILNSIV SIMITIPLDR GENIVLAYCE KMTKAPNQPL AKVCLQSLWR LFNNLDTASP
     LRYHVYYHLV QVAKQCDQVL EVFTGVDQLK SQFANCPPSS EQMQKLYRLL HDVTKDTNLE
     LSSKVMIELL GTYTADNACV AREDAMKCIV TALADPNTFL LDPLLSLKPV RFLEGDLIHD
     LLSIFVSDKL PSYVQFYEDH KEFVNSQGLN HDQNMKKMRL LTFMQLAESY PEMSFDTLTK
     ELQINDDEVE PFVIEVLKTK LVRARLDQAN RKVHISSTMH RTFGAPQWEQ LRDLLQAWKE
     NLSSVREGLT NVSSAQLDLA RTQKLIH