ID   EIF3M_DROMO             Reviewed;         387 AA.
AC   B4KT65;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
DE   AltName: Full=Transport and Golgi organization protein 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=Tango-7 {ECO:0000255|HAMAP-Rule:MF_03012};
GN   Name=Tango7 {ECO:0000255|HAMAP-Rule:MF_03012}; ORFNames=GI18957;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC       Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC       Rule:MF_03012}.
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DR   EMBL; CH933808; EDW09585.1; -; Genomic_DNA.
DR   RefSeq; XP_002005650.1; XM_002005614.2.
DR   AlphaFoldDB; B4KT65; -.
DR   SMR; B4KT65; -.
DR   STRING; 7230.FBpp0168174; -.
DR   EnsemblMetazoa; FBtr0169682; FBpp0168174; FBgn0141696.
DR   GeneID; 6579771; -.
DR   KEGG; dmo:Dmoj_GI18957; -.
DR   eggNOG; KOG2753; Eukaryota.
DR   HOGENOM; CLU_035254_1_0_1; -.
DR   InParanoid; B4KT65; -.
DR   OMA; REDAQRC; -.
DR   OrthoDB; 679771at2759; -.
DR   PhylomeDB; B4KT65; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03012; eIF3m; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR027528; eIF3m.
DR   InterPro; IPR040750; eIF3m_C_helix.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   Pfam; PF18005; eIF3m_C_helix; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Golgi apparatus; Initiation factor; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..387
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   M"
FT                   /id="PRO_0000366001"
FT   DOMAIN          181..340
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   387 AA;  44191 MW;  BDBB8366E43A677F CRC64;
     MTSHPVFIDL SLDEQVQELR KYFKKLGAEI SSEKSNKGVE DDLHKIIGVC EVCFKDGEPA
     QIDGILNSIV SIMITIPLDR GENIVLAYCE KMTKAPNQPL AKVCLQSLWR LFNNLDTASP
     LRYHVYYHLV QVAKQCDQVL EVFTGVDQLK SQFANCPPSS EQMQKLYRLL HDVTKDTNLE
     LSSKVMIELL GTYTADNACV AREDAMKCIV TALADPNTFL LDPLLSLKPV RFLEGDLIHD
     LLSIFVSDKL PSYVQFYEDH KEFVNSQGLN HEQNMKKMRL LTFMQLAESY PEMTFDTLTK
     ELQINEDEVE PFVIEVLKTK LVRARLDQAN RKVHISSTMH RTFGAPQWEQ LRDLLQAWKE
     NLSSVREGLT NVSSAQLDLA RSQKLIH