EIF3M_DROPE
ID EIF3M_DROPE Reviewed; 387 AA.
AC B4GDM5;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
DE AltName: Full=Transport and Golgi organization protein 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE Short=Tango-7 {ECO:0000255|HAMAP-Rule:MF_03012};
GN Name=Tango7 {ECO:0000255|HAMAP-Rule:MF_03012}; ORFNames=GL10828;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC Rule:MF_03012}.
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DR EMBL; CH479181; EDW31682.1; -; Genomic_DNA.
DR RefSeq; XP_002015792.1; XM_002015756.1.
DR AlphaFoldDB; B4GDM5; -.
DR SMR; B4GDM5; -.
DR STRING; 7234.FBpp0174935; -.
DR EnsemblMetazoa; FBtr0176443; FBpp0174935; FBgn0148438.
DR GeneID; 6591249; -.
DR KEGG; dpe:6591249; -.
DR eggNOG; KOG2753; Eukaryota.
DR HOGENOM; CLU_035254_1_0_1; -.
DR OMA; REDAQRC; -.
DR PhylomeDB; B4GDM5; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0070865; C:investment cone; IEA:EnsemblMetazoa.
DR GO; GO:0089720; F:caspase binding; IEA:EnsemblMetazoa.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IEA:EnsemblMetazoa.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0007030; P:Golgi organization; IEA:EnsemblMetazoa.
DR GO; GO:2001272; P:positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IEA:EnsemblMetazoa.
DR GO; GO:0009306; P:protein secretion; IEA:EnsemblMetazoa.
DR GO; GO:0007291; P:sperm individualization; IEA:EnsemblMetazoa.
DR HAMAP; MF_03012; eIF3m; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045237; COPS7/eIF3m.
DR InterPro; IPR027528; eIF3m.
DR InterPro; IPR040750; eIF3m_C_helix.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR15350; PTHR15350; 1.
DR Pfam; PF18005; eIF3m_C_helix; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Golgi apparatus; Initiation factor; Protein biosynthesis;
KW Reference proteome.
FT CHAIN 1..387
FT /note="Eukaryotic translation initiation factor 3 subunit
FT M"
FT /id="PRO_0000366002"
FT DOMAIN 181..340
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 387 AA; 44146 MW; 6FEC0C917CCCEB66 CRC64;
MTSHPVFIDL SLDEQVQELR KYFKKLGAEI SSEKSNKGVE DDLHKIIGVC DVCFKDGEPS
QIDGILNSIV SIMITIPLDR GENIVLAYCE KMTKAPNQPL GKVCLQSLWR LFNNLDTASP
LRYHVYYHLV QVAKQCEQVL EVFTGVDQLK TQFANCPPSS EQMQKLYRLL HDVTKDTNME
LSSKVMIELL GTYTADNACV AREDAMKCIV TALADPNTFL LDPLLALKPV RFLEGDLIHD
LLSIFVSDKL PSYVQFYEDH KEFVNSQGLN HEQNMKKMRL LTFMQLAESN PEMTFDTLTK
ELQITEDEVE PFVIQVLKTK LVRARLDQAN RKVHISSTMH RTFGAPQWEQ LRDLLQAWKE
NLSSVRDGLT NVSSAQLDLA RTQKLIH
