ID   EIF3M_DROSI             Reviewed;         387 AA.
AC   B4QFD2;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
DE   AltName: Full=Transport and Golgi organization protein 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=Tango-7 {ECO:0000255|HAMAP-Rule:MF_03012};
GN   Name=Tango7 {ECO:0000255|HAMAP-Rule:MF_03012}; ORFNames=GD25700;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC       Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC       Rule:MF_03012}.
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DR   EMBL; CM000362; EDX07042.1; -; Genomic_DNA.
DR   RefSeq; XP_002081457.1; XM_002081421.2.
DR   AlphaFoldDB; B4QFD2; -.
DR   SMR; B4QFD2; -.
DR   STRING; 7240.B4QFD2; -.
DR   EnsemblMetazoa; FBtr0225610; FBpp0224102; FBgn0196985.
DR   GeneID; 6734437; -.
DR   HOGENOM; CLU_035254_1_0_1; -.
DR   OMA; REDAQRC; -.
DR   PhylomeDB; B4QFD2; -.
DR   Proteomes; UP000000304; Chromosome 2r.
DR   Bgee; FBgn0196985; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0070865; C:investment cone; IEA:EnsemblMetazoa.
DR   GO; GO:0089720; F:caspase binding; IEA:EnsemblMetazoa.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IEA:EnsemblMetazoa.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0007030; P:Golgi organization; IEA:EnsemblMetazoa.
DR   GO; GO:2001272; P:positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IEA:EnsemblMetazoa.
DR   GO; GO:0009306; P:protein secretion; IEA:EnsemblMetazoa.
DR   GO; GO:0007291; P:sperm individualization; IEA:EnsemblMetazoa.
DR   HAMAP; MF_03012; eIF3m; 1.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR027528; eIF3m.
DR   InterPro; IPR040750; eIF3m_C_helix.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   Pfam; PF18005; eIF3m_C_helix; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Golgi apparatus; Initiation factor; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..387
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   M"
FT                   /id="PRO_0000366004"
FT   DOMAIN          181..340
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   387 AA;  44087 MW;  F750DEEAA6E4A017 CRC64;
     MTSHPVFIDL SLDEQVQELR KYFKKLGAEI SSEKSNKGVE DDLHKIIGVC DVCFKDGEPS
     QIDGILNSIV SIMITIPLDR GENIVLAYCE KMTKAPNLPL GKVCLQSLWR LFNNLDTASP
     LRYHVYYHLV QVAKQCEQVL EVFSGVDQLK SQFANCPPSS EQMQKLYRLL HDVTKDTNLE
     LSSKVMIELL GTYTADNACV AREDAMKCIV TALADPNTFL LDPLLSLKPV RFLEGDLIHD
     LLSIFVSEKL PAYVQFYEDH REFVNSQGLN HEQNMKKMRL LTFMQLAESS PEMTFETLTK
     ELQINEDEVE PFVIEVLKTK LVRARLDQAN QKVHISSTMH RTFGAPQWEQ LRDLLQAWKE
     NLSTVREGLT SVSSAQLDLA RSQKLIH