EIF3M_DROYA
ID EIF3M_DROYA Reviewed; 387 AA.
AC B4P6M6; Q6XIK5;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
DE AltName: Full=Transport and Golgi organization protein 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE Short=Tango-7 {ECO:0000255|HAMAP-Rule:MF_03012};
GN Name=Tango7 {ECO:0000255|HAMAP-Rule:MF_03012}; ORFNames=GE12333;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-225.
RX PubMed=14525923; DOI=10.1101/gr.1311003;
RA Domazet-Loso T., Tautz D.;
RT "An evolutionary analysis of orphan genes in Drosophila.";
RL Genome Res. 13:2213-2219(2003).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC Rule:MF_03012}.
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DR EMBL; CM000158; EDW90978.1; -; Genomic_DNA.
DR EMBL; AY231825; AAR09848.1; -; mRNA.
DR RefSeq; XP_002091266.1; XM_002091230.2.
DR AlphaFoldDB; B4P6M6; -.
DR SMR; B4P6M6; -.
DR STRING; 7245.FBpp0257343; -.
DR EnsemblMetazoa; FBtr0258851; FBpp0257343; FBgn0068224.
DR GeneID; 6530339; -.
DR KEGG; dya:Dyak_GE12333; -.
DR eggNOG; KOG2753; Eukaryota.
DR HOGENOM; CLU_035254_1_0_1; -.
DR OMA; REDAQRC; -.
DR OrthoDB; 679771at2759; -.
DR PhylomeDB; B4P6M6; -.
DR Proteomes; UP000002282; Chromosome 2R.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0070865; C:investment cone; IEA:EnsemblMetazoa.
DR GO; GO:0089720; F:caspase binding; IEA:EnsemblMetazoa.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IEA:EnsemblMetazoa.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0007030; P:Golgi organization; IEA:EnsemblMetazoa.
DR GO; GO:2001272; P:positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IEA:EnsemblMetazoa.
DR GO; GO:0009306; P:protein secretion; IEA:EnsemblMetazoa.
DR GO; GO:0007291; P:sperm individualization; IEA:EnsemblMetazoa.
DR HAMAP; MF_03012; eIF3m; 1.
DR InterPro; IPR045237; COPS7/eIF3m.
DR InterPro; IPR027528; eIF3m.
DR InterPro; IPR040750; eIF3m_C_helix.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR15350; PTHR15350; 1.
DR Pfam; PF18005; eIF3m_C_helix; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Golgi apparatus; Initiation factor; Protein biosynthesis.
FT CHAIN 1..387
FT /note="Eukaryotic translation initiation factor 3 subunit
FT M"
FT /id="PRO_0000366007"
FT DOMAIN 181..340
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 387 AA; 44094 MW; 689CE959572F9009 CRC64;
MTSHPVFIDL SLDEQVQELR KYFKKLGAEI SSEKSNKGVE DDLHKIIGVC DVCFKDGEPS
QIDGILNSIV SIMITIPLDR GENIVLAYCE KMTKAPNLPL GKVCLQSLWR LFNNLDTASP
LRYHVYYHLV QVAKQCEQVL EVFTGVDQLK SQFANCPPSS EQMQKLYRLL HDVTKDTNLE
LSSKVMIELL GTYTADNACV AREDAMKCIV TALADPNTFL LDPLLALKPV RFLEGDLIHD
LLSIFVSEKL PAYVQFYEDH REFVNSQGLN HEQNMKKMRL LTFMQLAESS PEMTFETLTK
ELQINEDEVE PFVIEVLKTK LVRARLDQAN HKVHITSTMH RTFGAPQWEQ LRDLLQAWKE
NLSTVREGLT SVSSAQVDLA RSQKLIH
