ID   EIF3M_XENLA             Reviewed;         374 AA.
AC   Q7ZYU8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
GN   Name=eif3m;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC       eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC       eif3m. {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC       Rule:MF_03012}.
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DR   EMBL; BC041198; AAH41198.1; -; mRNA.
DR   RefSeq; NP_001080061.1; NM_001086592.1.
DR   AlphaFoldDB; Q7ZYU8; -.
DR   SMR; Q7ZYU8; -.
DR   BioGRID; 97995; 2.
DR   IntAct; Q7ZYU8; 1.
DR   DNASU; 379753; -.
DR   GeneID; 379753; -.
DR   KEGG; xla:379753; -.
DR   CTD; 379753; -.
DR   Xenbase; XB-GENE-968611; eif3m.S.
DR   OMA; VFGKHEW; -.
DR   OrthoDB; 679771at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 379753; Expressed in spleen and 19 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03012; eIF3m; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR027528; eIF3m.
DR   InterPro; IPR040750; eIF3m_C_helix.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   Pfam; PF18005; eIF3m_C_helix; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..374
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   M"
FT                   /id="PRO_0000308200"
FT   DOMAIN          180..339
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   374 AA;  42306 MW;  957CD18E511B24F0 CRC64;
     MSVPAFIDVT EEDQAAELRA YLKSKGAEIS EENSEGGLHI DLAQIIEACD VCLKDDDKDV
     ESSMNSVVSL VLILETDKQE ALIESLCEKL VKSREGERPS LRLQLLSNLF HGMDKSIPAR
     YTVYCALIKV AATCGGIVYI PTDLDQVRKW ISDWNLSTEK KHVVLRLLYE ALVDCKKSDE
     AAKVMVELLG SYTDDNASQA RLDAHKCIVR ALKDPKAFLL DHLLALKPVK FLEGELIHDL
     LTIFVSAKLS SYVKFYQNNK DFIDSLGLSH EQNMEKMRLL TFMGMAVDNK EISFDTIQQE
     LQMGADEVEA FIIDAVKTKM VYCKIDQTQK KVVVSHSTHR TFGKQQWQQL YDILNTWKLN
     LNKVKNSLYS ISDA