ID   EIF3M_XENTR             Reviewed;         374 AA.
AC   Q6DK91;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE            Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
GN   Name=eif3m; ORFNames=TGas135n07.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC       eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC       eif3m. {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC       Rule:MF_03012}.
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DR   EMBL; CR761845; CAJ83840.1; -; mRNA.
DR   EMBL; BC074530; AAH74530.1; -; mRNA.
DR   RefSeq; NP_001004794.1; NM_001004794.1.
DR   AlphaFoldDB; Q6DK91; -.
DR   SMR; Q6DK91; -.
DR   STRING; 8364.ENSXETP00000017921; -.
DR   PaxDb; Q6DK91; -.
DR   DNASU; 448014; -.
DR   Ensembl; ENSXETT00000017921; ENSXETP00000017921; ENSXETG00000008167.
DR   GeneID; 448014; -.
DR   KEGG; xtr:448014; -.
DR   CTD; 10480; -.
DR   Xenbase; XB-GENE-968605; eif3m.
DR   eggNOG; KOG2753; Eukaryota.
DR   HOGENOM; CLU_035254_1_0_1; -.
DR   InParanoid; Q6DK91; -.
DR   OMA; VFGKHEW; -.
DR   OrthoDB; 679771at2759; -.
DR   PhylomeDB; Q6DK91; -.
DR   TreeFam; TF106148; -.
DR   Reactome; R-XTR-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-XTR-72649; Translation initiation complex formation.
DR   Reactome; R-XTR-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-XTR-72702; Ribosomal scanning and start codon recognition.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008167; Expressed in neurula embryo and 23 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03012; eIF3m; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR027528; eIF3m.
DR   InterPro; IPR040750; eIF3m_C_helix.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   Pfam; PF18005; eIF3m_C_helix; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..374
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   M"
FT                   /id="PRO_0000308201"
FT   DOMAIN          180..339
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   374 AA;  42407 MW;  6F3FC23DFAF1357D CRC64;
     MSVPAFIDVT EEDQAAELRA YLKSKGAEIS EENSEGGLHI DLAQIIEACD VCLKDDDKDV
     ESSMNSVVSL VLILETDKQE ALIESLCEKL VKFREGERPS LRLQLLSNLF HGMDKSIPAR
     YTVYCGLIKV AATCGAIIYI PTDLDQVRKW ISDWNLSTEK KHIVLRLLYE ALVDCKKSDE
     AAKVMVELLG SYTDDNASQA RLDAHKCIVR ALKDPKAFLL DHLLALKPVK FLEGELIHDL
     LTIFVSAKLS SYVKFYQNNK DFIDSLGLSH EQNMEKMRLL TFMGMAVDNK EISFDTIQQE
     LQIGADEVEA FIIDAVKTKM VYCKIDQTQK RVVVSHSTHR TFGKQQWQQL YDTLNTWKQN
     LNKVKNSLYS ISDA