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EIL1_ARATH
ID   EIL1_ARATH              Reviewed;         584 AA.
AC   Q9SLH0; O23114;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=ETHYLENE INSENSITIVE 3-like 1 protein;
GN   Name=EIL1; OrderedLocusNames=At2g27050; ORFNames=T20P8.10;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=cv. Columbia;
RX   PubMed=9215635; DOI=10.1016/s0092-8674(00)80300-1;
RA   Chao Q., Rothenberg M., Solano R., Roman G., Terzaghi W., Ecker J.R.;
RT   "Activation of the ethylene gas response pathway in Arabidopsis by the
RT   nuclear protein ETHYLENE-INSENSITIVE3 and related proteins.";
RL   Cell 89:1133-1144(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   CHARACTERIZATION, AND FUNCTION.
RX   PubMed=9851977; DOI=10.1101/gad.12.23.3703;
RA   Solano R., Stepanova A.N., Chao Q., Ecker J.R.;
RT   "Nuclear events in ethylene signaling: a transcriptional cascade mediated
RT   by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1.";
RL   Genes Dev. 12:3703-3714(1998).
RN   [6]
RP   CHARACTERIZATION, AND MUTANTS EIL1-1 AND EIL1-2.
RX   PubMed=12606727; DOI=10.1073/pnas.0438070100;
RA   Alonso J.M., Stepanova A.N., Solano R., Wisman E., Ferrari S.,
RA   Ausubel F.M., Ecker J.R.;
RT   "Five components of the ethylene-response pathway identified in a screen
RT   for weak ethylene-insensitive mutants in Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:2992-2997(2003).
CC   -!- FUNCTION: Probable transcription factor acting as a positive regulator
CC       in the ethylene response pathway. Could bind the primary ethylene
CC       response element present in the ETHYLENE-RESPONSE-FACTOR1 promoter.
CC       {ECO:0000269|PubMed:9215635, ECO:0000269|PubMed:9851977}.
CC   -!- SUBUNIT: Acts as homodimer to bind the primary ethylene response
CC       element. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: Loss-of-function mutations (EIL1-1 and EIL1-2) in the
CC       gene show a weak ethylene-insensitive phenotype.
CC   -!- SIMILARITY: Belongs to the EIN3 family. {ECO:0000305}.
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DR   EMBL; AF004213; AAC49746.1; -; mRNA.
DR   EMBL; AC005623; AAC77863.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC07930.1; -; Genomic_DNA.
DR   EMBL; AY065191; AAL38367.1; -; mRNA.
DR   EMBL; BT003344; AAO29962.1; -; mRNA.
DR   PIR; B84668; B84668.
DR   RefSeq; NP_180273.1; NM_128263.5.
DR   AlphaFoldDB; Q9SLH0; -.
DR   SMR; Q9SLH0; -.
DR   BioGRID; 2599; 14.
DR   DIP; DIP-34866N; -.
DR   IntAct; Q9SLH0; 21.
DR   STRING; 3702.AT2G27050.1; -.
DR   PaxDb; Q9SLH0; -.
DR   PRIDE; Q9SLH0; -.
DR   ProteomicsDB; 224495; -.
DR   EnsemblPlants; AT2G27050.1; AT2G27050.1; AT2G27050.
DR   GeneID; 817247; -.
DR   Gramene; AT2G27050.1; AT2G27050.1; AT2G27050.
DR   KEGG; ath:AT2G27050; -.
DR   Araport; AT2G27050; -.
DR   TAIR; locus:2059247; AT2G27050.
DR   eggNOG; ENOG502QQSG; Eukaryota.
DR   HOGENOM; CLU_027306_0_0_1; -.
DR   InParanoid; Q9SLH0; -.
DR   OMA; MDFFGAF; -.
DR   OrthoDB; 266873at2759; -.
DR   PhylomeDB; Q9SLH0; -.
DR   PRO; PR:Q9SLH0; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SLH0; baseline and differential.
DR   Genevisible; Q9SLH0; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0009970; P:cellular response to sulfate starvation; IMP:TAIR.
DR   GO; GO:0042742; P:defense response to bacterium; IGI:TAIR.
DR   GO; GO:0009873; P:ethylene-activated signaling pathway; TAS:TAIR.
DR   GO; GO:0009723; P:response to ethylene; IMP:TAIR.
DR   Gene3D; 1.10.3180.10; -; 2.
DR   InterPro; IPR006957; EIN3.
DR   InterPro; IPR023278; Ethylene_insens-like_DNA-bd.
DR   PANTHER; PTHR33305; PTHR33305; 2.
DR   Pfam; PF04873; EIN3; 1.
DR   SUPFAM; SSF116768; SSF116768; 1.
PE   1: Evidence at protein level;
KW   Activator; Coiled coil; DNA-binding; Ethylene signaling pathway; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..584
FT                   /note="ETHYLENE INSENSITIVE 3-like 1 protein"
FT                   /id="PRO_0000113499"
FT   REGION          67..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          565..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          41..74
FT                   /evidence="ECO:0000255"
FT   CONFLICT        74
FT                   /note="E -> G (in Ref. 1; AAC49746)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   584 AA;  66495 MW;  471E1715D1483B11 CRC64;
     MMMFNEMGMY GNMDFFSSST SLDVCPLPQA EQEPVVEDVD YTDDEMDVDE LEKRMWRDKM
     RLKRLKEQQS KCKEGVDGSK QRQSQEQARR KKMSRAQDGI LKYMLKMMEV CKAQGFVYGI
     IPEKGKPVTG ASDNLREWWK DKVRFDRNGP AAIAKYQSEN NISGGSNDCN SLVGPTPHTL
     QELQDTTLGS LLSALMQHCD PPQRRFPLEK GVSPPWWPNG NEEWWPQLGL PNEQGPPPYK
     KPHDLKKAWK VGVLTAVIKH MSPDIAKIRK LVRQSKCLQD KMTAKESATW LAIINQEEVV
     ARELYPESCP PLSSSSSLGS GSLLINDCSE YDVEGFEKEQ HGFDVEERKP EIVMMHPLAS
     FGVAKMQHFP IKEEVATTVN LEFTRKRKQN NDMNVMVMDR SAGYTCENGQ CPHSKMNLGF
     QDRSSRDNHQ MVCPYRDNRL AYGASKFHMG GMKLVVPQQP VQPIDLSGVG VPENGQKMIT
     ELMAMYDRNV QSNQTPPTLM ENQSMVIDAK AAQNQQLNFN SGNQMFMQQG TNNGVNNRFQ
     MVFDSTPFDM AAFDYRDDWQ TGAMEGMGKQ QQQQQQQQDV SIWF
 
 
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