EIPR1_DICDI
ID EIPR1_DICDI Reviewed; 400 AA.
AC Q86A97; Q555S9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=EARP-interacting protein homolog {ECO:0000250|UniProtKB:Q5PPK9};
GN Name=eipr1 {ECO:0000250|UniProtKB:Q5PPK9}; Synonyms=tssc1;
GN ORFNames=DDB_G0274279;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- SIMILARITY: Belongs to the WD repeat EIPR1 family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70032.1; -; Genomic_DNA.
DR RefSeq; XP_643981.1; XM_638889.1.
DR AlphaFoldDB; Q86A97; -.
DR SMR; Q86A97; -.
DR STRING; 44689.DDB0234267; -.
DR PaxDb; Q86A97; -.
DR EnsemblProtists; EAL70032; EAL70032; DDB_G0274279.
DR GeneID; 8619407; -.
DR KEGG; ddi:DDB_G0274279; -.
DR dictyBase; DDB_G0274279; tssc1.
DR eggNOG; KOG1007; Eukaryota.
DR HOGENOM; CLU_050772_0_0_1; -.
DR InParanoid; Q86A97; -.
DR OMA; HQFLALH; -.
DR PhylomeDB; Q86A97; -.
DR PRO; PR:Q86A97; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR040323; EIPR1.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR PANTHER; PTHR14205; PTHR14205; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..400
FT /note="EARP-interacting protein homolog"
FT /id="PRO_0000327928"
FT REPEAT 138..178
FT /note="WD 1"
FT REPEAT 227..267
FT /note="WD 2"
FT REPEAT 271..311
FT /note="WD 3"
FT REPEAT 358..397
FT /note="WD 4"
FT REGION 95..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 45485 MW; 0CFCB96B4B027523 CRC64;
MFNTNTSNIS TNVYGLSQKT RALSHITAEA DVNRFLVGTT ALREENEIAL LEAKEGEGVR
CLSIFPHPKE IHSITSCPFD SSLFFSVYNT SGGGNNNSNN TNNNDNTNNN TNNNDFKSSL
WRINESMDSI EELFELKGHT GIIKPILCDP SGSNNFIISL DDSNIRLWSK IDDQNEPTVI
KQFGNLSKLS VGSINPNISN QLATANDVNI KGWDFRNAKE TFSMDKAHSE QIRDIDFNPN
KPYYLLSAGD DCKLKIWDTR QTRDPVKIFS GHNHWIWSAK FNRYHDQLII TSSSDNTVKL
WNLYSLSSAF NSENNISNSN EQQHSQQPNE QQPQQPPQPV KQKKNKRNED QLIKTYEEHE
DSVYNISWSS SNFLFASLSY DGRFVVNNVP KEYSDILSYI
