ID   EIS1_CANGA              Reviewed;         885 AA.
AC   Q6FKB4;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Eisosome protein 1;
GN   Name=EIS1; OrderedLocusNames=CAGL0L12914g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for normal formation of eisosomes, large cytoplasmic
CC       protein assemblies that localize to specialized domains on plasma
CC       membrane and mark the site of endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes at the eisosomes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EIS1 family. {ECO:0000305}.
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DR   EMBL; CR380958; CAG62304.1; -; Genomic_DNA.
DR   RefSeq; XP_449330.1; XM_449330.1.
DR   AlphaFoldDB; Q6FKB4; -.
DR   SMR; Q6FKB4; -.
DR   STRING; 5478.XP_449330.1; -.
DR   PRIDE; Q6FKB4; -.
DR   EnsemblFungi; CAG62304; CAG62304; CAGL0L12914g.
DR   GeneID; 2890580; -.
DR   KEGG; cgr:CAGL0L12914g; -.
DR   CGD; CAL0135934; CAGL0L12914g.
DR   VEuPathDB; FungiDB:CAGL0L12914g; -.
DR   eggNOG; ENOG502S8WV; Eukaryota.
DR   HOGENOM; CLU_013228_0_0_1; -.
DR   InParanoid; Q6FKB4; -.
DR   OMA; EHTFSGF; -.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0032126; C:eisosome; IEA:EnsemblFungi.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070941; P:eisosome assembly; IEA:EnsemblFungi.
DR   InterPro; IPR024527; Eisosome1.
DR   PANTHER; PTHR28298; PTHR28298; 2.
DR   Pfam; PF12757; Eisosome1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..885
FT                   /note="Eisosome protein 1"
FT                   /id="PRO_0000410799"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          695..885
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..722
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        756..800
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        815..851
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        852..868
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        869..885
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   885 AA;  97546 MW;  325C778DBE025364 CRC64;
     MSLISTVDDH TQDTASVASG SSATKKKYNP KVYHDDNQPL SKEAMYRAKL KYGVYNSPIS
     GGVGVGVTDY KAATNKAANV ANDNQTTVEA YRRLYVDQGA ASAALKVGTE PVREKPDVHA
     EKFKQNRALN LNYTSAAAKA LSVGTEKLFT ASEEARHAGQ KTYSIVSQVS AASTSRAMDM
     SKVLKGAERK AESRLKERSE PERKEYVKSY SMTAGAAADY GAAGGAAGAA GAAGAASRSI
     DLNSDVMARV AKRSELPPKQ EGPTEKERNA AKFALGAATA VKDLDPKSML PEDFAAREQQ
     RQEFVRHMTS QKVLSMAREK VDREMASIDK QQAERRLYDN DSYNRAAVAI AQQNYQNKLN
     AQSEKAGKIN IGGGLFLTPQ EVDNIAHGLI SPVLGEVSER AEAQRAADTE IATRIATYEK
     DLSNWKNLQR TKQTNDKNVL EVNSKRIALE KQEAKDAAQK KYDEMIKKMD ETVAEKKKQL
     EAAKQRLEDL QEEMNMKLGM QDQKVEEELQ KWDENREKDI EAARLEQEEL VKPFQDELDE
     AEKQHEEFLK ERDGIDTEIT GLQEAIEGHK KKIEIYEGDI RAHDNMHVEE GGKLENLGQN
     KETLANTLNN DIIILANKTK EQAELSTKQA RLKQLEVDAM VNERKSELNQ TEIQLKKEKL
     QLLESMRNKA QARGDEKIDE EKVKGLFGMT SEEYLAKHAP KKEEPAEEKL ETVAEEASAM
     KKEKPTAAAA TTAAAAAATT PKKPASAPRA APAAASPKSE KKRKGSVFDK FFLGPRKAHM
     IEETRTNQKV AEEKAKMDSV SKPHLVSTTN EHAKPHAAAT EEAPKKVDAP KPATEVKSSE
     AAEDEENKLE HTFSGFSQGS VADDKGTTSG AHSETKKDGY FKEVF