ID   EIS1_KLULA              Reviewed;         830 AA.
AC   Q6CTI0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Eisosome protein 1;
GN   Name=EIS1; OrderedLocusNames=KLLA0C12573g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for normal formation of eisosomes, large cytoplasmic
CC       protein assemblies that localize to specialized domains on plasma
CC       membrane and mark the site of endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes at the eisosomes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EIS1 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01610.1; -; Genomic_DNA.
DR   RefSeq; XP_452759.1; XM_452759.1.
DR   AlphaFoldDB; Q6CTI0; -.
DR   SMR; Q6CTI0; -.
DR   STRING; 28985.XP_452759.1; -.
DR   EnsemblFungi; CAH01610; CAH01610; KLLA0_C12573g.
DR   GeneID; 2892410; -.
DR   KEGG; kla:KLLA0_C12573g; -.
DR   eggNOG; ENOG502S8WV; Eukaryota.
DR   HOGENOM; CLU_013228_1_0_1; -.
DR   InParanoid; Q6CTI0; -.
DR   OMA; EHTFSGF; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024527; Eisosome1.
DR   PANTHER; PTHR28298; PTHR28298; 2.
DR   Pfam; PF12757; Eisosome1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..830
FT                   /note="Eisosome protein 1"
FT                   /id="PRO_0000410800"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          650..830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        668..683
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        712..726
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        734..767
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        777..802
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        803..830
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   830 AA;  91232 MW;  24C5E0599F8A1751 CRC64;
     MSLVSAVTGD ESRDTNGAEQ SSVYQSAGKP LSKEALYRAK LKYGVFQSPA QSLKAGVVNG
     KDASDTAANL ATSNKTTIEA YKRLLNPNAS KAANAVITPK KTDQSRPASA VVSSAASSAA
     IAAPKAARSR TSSTASTTVT YVNSSSSSPL HSKTPKMDIT KVLAGAERNA AESVHQRTNP
     EKVSYVRGIT DRSVGKAADA SFSLTSDIVS NLPTKKEYIQ SAEKESHAAE WAQKAVAALK
     DFNPDDVTDK NWREREEERK RLIKNLTSET VLTKAKLNAQ QRLDTIDRET SQRAIFRNAE
     YNRAAASVAQ ENLRKTRSSA SATANKVNLG GGLWLAPDDI DNIAKGLIAP VLDEVDQRTG
     AQRAMDIDIQ KRSVDYQQQY EEWVNIQTEK QNNDSLLQAK AFENHQKETA DIEATLAKKF
     QNLCTQKDSE VAKLKEALEA KKAELAKLKE DNEEELKRED EMITTECADL QKSNENELEQ
     AKKDQEELLV PFKNDLAAAE DHHTELQDQK GKIEENIQEL RDSIEKHKSH VEELNAQIET
     QQQQLETETE ALNLQSESHQ QLKDGIETNY VIMAEKAKEE AKVSSEEARV KQLEVDAIIN
     ERQTELSNTE IEVKREKLKL IDAMKEVAEV KNEDKIDEEK AKAFLGTTSG EFLASQKKVE
     PATKLQSDPK LSEPSSKSTK IEGVTGNVKA DVPASPPAHK KHSIGGLTSP LKSKKKSDKD
     QKGSSIKKFF GLKPSDQNKN TKTTQPTPLK SSPKPSNKPV TATVTTEKKE NVEPKSTATE
     TKPSLEPSFS GFSQGSVHNK VEQSDASEVE GGKEEPTSKD NRKSLFKEVF