ID   EIS1_LACTC              Reviewed;         930 AA.
AC   C5DGV3;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Eisosome protein 1;
GN   Name=EIS1; OrderedLocusNames=KLTH0D08558g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Required for normal formation of eisosomes, large cytoplasmic
CC       protein assemblies that localize to specialized domains on plasma
CC       membrane and mark the site of endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes at the eisosomes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EIS1 family. {ECO:0000305}.
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DR   EMBL; CU928168; CAR22645.1; -; Genomic_DNA.
DR   RefSeq; XP_002553083.1; XM_002553037.1.
DR   AlphaFoldDB; C5DGV3; -.
DR   SMR; C5DGV3; -.
DR   STRING; 559295.C5DGV3; -.
DR   EnsemblFungi; CAR22645; CAR22645; KLTH0D08558g.
DR   GeneID; 8295319; -.
DR   KEGG; lth:KLTH0D08558g; -.
DR   eggNOG; ENOG502S8WV; Eukaryota.
DR   HOGENOM; CLU_013228_1_0_1; -.
DR   InParanoid; C5DGV3; -.
DR   OrthoDB; 948571at2759; -.
DR   Proteomes; UP000002036; Chromosome D.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024527; Eisosome1.
DR   PANTHER; PTHR28298; PTHR28298; 2.
DR   Pfam; PF12757; Eisosome1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..930
FT                   /note="Eisosome protein 1"
FT                   /id="PRO_0000410801"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          516..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          637..930
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        642..669
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..695
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        847..865
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        880..894
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   930 AA;  101460 MW;  03BD1F9EBA17E557 CRC64;
     MSLISAAADV NDASSTTSAG SVRSSAVYRK DGKPLSQEAL YRAQQKYGVF QSPARQTGSG
     LKDSKMASDV AANLANNNRT TIEAYKRVLD SNASRAATAV SSRSRSSSVT SNATVVTTSS
     KSTNAAVKAL SSKPVEQPVA PKKSNMNMSK ILVGAEAAAE KRIGIRMKPE KIVYVPSKES
     GKAAERSMSL TPEIMDKLKT KGDYEAEAEV EADPKKYASK AAFAVRDFDP NEATEKELLE
     REKKKQAYFG MLTSPQVLSL ARANAQVKLD QIDKAAPGSL YKNEEFNKLA VALAQKNSTK
     RSEHHGKINM GGGLWLTQAD VQNIAQGLIT PVLDEVDSRA LQQRAIDEDI KQRKIDFKEQ
     NAAWIELQRN KLSNDKMYSR ETRMRHKRET EGLHARTERK FQDLCASKDS EVAEMEKALQ
     NAKDSYAALQ KQMEEDLEKE RLRVEAEVAA LKKEQEEDLK AARVEQEQEL KPYVDDVKAA
     EAEHERLTAE RDSLNKEIEE LRASIESHKV RIEELDNEIS DSAAKHEEEE GKREELTKHK
     EEFDQEVSEK FTVIAQAAKE KAQKSSEEAR LKQLEVDAMI NERQSELNST ELELKKEKLS
     LLEAMRNVTE LKGEDKLDEN RVKALIGMTS EEFIAENNKS VNVSDDKFEP FNEHTASTKS
     IKHEEGVLGE GGAKTNSDEL PVKDSAEKSS EHLNSTAEKS IEPAKASSPY PAKPSMVDAV
     LPKDFKPEVK PKAKPAHKTP QQGAAAGGEP ASAKSGVKRS PSLKQKFMGI IKGDTKSQSK
     PAAAATPVHP PATVKKAAPK KAAASSEADT PAKVSPAKDT AKTEIQKIAQ GGPAPAPEPE
     HKTAPAVDNA TTKSVSTLQK PTNSGIDKSE IHKIAQGGPA PTSGHSNHTR TSVYENGDNS
     DDEDELPDSS EAGENGIGAD KKGSLFKEVF