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EIS1_YEAS7
ID   EIS1_YEAS7              Reviewed;         843 AA.
AC   A6ZM93;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Eisosome protein 1;
GN   Name=EIS1; ORFNames=SCY_4205;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Required for normal formation of eisosomes, large cytoplasmic
CC       protein assemblies that localize to specialized domains on plasma
CC       membrane and mark the site of endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes at the eisosomes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EIS1 family. {ECO:0000305}.
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DR   EMBL; AAFW02000020; EDN64423.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZM93; -.
DR   SMR; A6ZM93; -.
DR   EnsemblFungi; EDN64423; EDN64423; SCY_4205.
DR   HOGENOM; CLU_013228_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024527; Eisosome1.
DR   PANTHER; PTHR28298; PTHR28298; 1.
DR   Pfam; PF12757; Eisosome1; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cell membrane; Membrane; Phosphoprotein.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   CHAIN           2..843
FT                   /note="Eisosome protein 1"
FT                   /id="PRO_0000410805"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          718..843
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        718..740
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        772..797
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        798..834
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         88
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         130
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         182
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         401
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         584
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         710
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         720
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         763
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         775
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         816
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         828
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         829
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
FT   MOD_RES         838
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05050"
SQ   SEQUENCE   843 AA;  93195 MW;  015B1FB8DC3ADF83 CRC64;
     MSLISAVEDR DIHNIGKTSG GGSRTSSITS SKKSLKHGSK SLRKPKVYQT TGEPLSREAL
     YKAKLKYGVY QSPAQSYSIG VSDAHAASDK AANLAHDNQT TVEAYKRMFI DPNATKAASK
     MGPKVVRNNS ITSATSKTSK ESQTKRKSKE SPGAAASKAY SMTMETTSLS SQTNSRSYSI
     TSASSVLSGA SGSFNSTVNP KPKTLNLEKV LVGAEKKAES RIKERWEPEK TNFQYGVKTD
     EHGNLNQFSF SNEMMNNIMA KVDAPKAQDL QKVKKVSAEK EAKSMKFALG AANAVKDMHP
     GADIDKSIAL KAQKRETYLS QLTSQQVLTL ARANVDRQLD IIEKSDMHRK LFTNMEYNKA
     AVAVAQSNHQ KKTEFHNKIN MGGGLFLSPE DITKIASGLI SPVLGEVSER AEAQRAMDEE
     IAERTEAYNK SLNEWETMER SIISNDAKVL TTTANRHQTE KKTSQEKIKA SFDALVARMD
     TKVAERETLL EDTKNKEIEF KKQMQQELKD EKARLDQDLE EWGKKCEQDI TEARKEQEEL
     LKPYHDDLAN AEAEHKTLVE ERDAINAEIS RLQDAIVDHK RKISGYGNDL DAQKNRNIRE
     DDKLLELGQT KESLESHLND DVIILANKAK EQAELSTKEA RLKQLEVDSL INERKSELNA
     TEIELKKEKL NLLEAMKDVA SARGDDKIAE EKVKKLIGMT SEEYLTQNKS VEKNVEDLPT
     QLEKIEEGDE LKKEEIVGAE TKNSGGDGVP VSTGAKEAAE TSSAVQTKEP EEKISIGNKS
     SGKEDANDCE SAEHSKEISV SQKAGNNKSL GVSPDSLEHT FSGFSQGSSI EDDQDAISNQ
     EKK
 
 
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