ID   EIS1_ZYGRC              Reviewed;         848 AA.
AC   C5DX05;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Eisosome protein 1;
GN   Name=EIS1; OrderedLocusNames=ZYRO0F01188g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Required for normal formation of eisosomes, large cytoplasmic
CC       protein assemblies that localize to specialized domains on plasma
CC       membrane and mark the site of endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes at the eisosomes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EIS1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU928178; CAR28316.1; -; Genomic_DNA.
DR   RefSeq; XP_002497249.1; XM_002497204.1.
DR   AlphaFoldDB; C5DX05; -.
DR   SMR; C5DX05; -.
DR   STRING; 559307.C5DX05; -.
DR   PRIDE; C5DX05; -.
DR   EnsemblFungi; CAR28316; CAR28316; ZYRO0F01188g.
DR   GeneID; 8205002; -.
DR   KEGG; zro:ZYRO0F01188g; -.
DR   HOGENOM; CLU_013228_0_0_1; -.
DR   InParanoid; C5DX05; -.
DR   Proteomes; UP000008536; Chromosome F.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024527; Eisosome1.
DR   PANTHER; PTHR28298; PTHR28298; 2.
DR   Pfam; PF12757; Eisosome1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..848
FT                   /note="Eisosome protein 1"
FT                   /id="PRO_0000410808"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          496..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          712..848
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..236
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        712..764
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        768..814
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        815..833
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   848 AA;  94830 MW;  CF5BFCDFD9C7CC03 CRC64;
     MSLVSTVNDA ERTDLLNSSG NRNGPVVETV TTTAVEEKPI TTKSVRGFSV YHKGGGAQLS
     KEALYRAKVK YGIYQSPARS FSTGVAEPKV ASDVAANLAN DNKTTIEAYK RLFVDPNANT
     AARRSIVNGG PRVEDVVIPE SHYGSHQAAT RAYSVASVAT DENARRLQSP QSPPATRAHS
     LKSANKAFYN TKLPEQVEVV PKQVGKKPMD MSKILSSAEN RAQHRVTDRW DPVKADHGIR
     TSTQNLNRVR STSLTGPIYK ERKGVKEPSS KDASATQGDR GNYAQWAAFA VRDMDPTALT
     NKEFEERERA KRELLSQITS QQVLAKAREN ADKQLDAIDA NDVHRVLFGN DAYNRAAIEI
     AQRNAQRQAG ETDVNEGKIN IGGGLWLSPD DVHTIAREMV DPVLGEVHQR ADDQRATDVD
     IKERNDYVTN EWNAWTAMHQ TKENNNEALL VNSQNKRTRE ADSARSEAEK SFTELCDRMD
     KQVAERNDLL NQTKQAREQL ERETEEKLAQ NKEDNKTALR DLKGQHAKEL EEAREEQRRL
     VQPYEERLEE VNREHESLVQ ERTAINEEIA RLHESIKEHQ YQISKYEREI KSHEEQNASA
     EEELKKLETD REGIQSHYND NVVVNANKAK EQALLSSEEA RLQNLKVDAI INERKTELNR
     TEQELQREKL NMLEAMRKTA EARGDENIDE ERVKQLIGMT STEYVEEQKK LQKAAGKAEK
     PKASTADKGQ ALDKALAHDQ GDQEANTKDF KEGAETKAKE SKGKPSQSVA KAIATSPTKT
     EAKAEPSTSK GKSNGVGTHP DNASGISQIS DTLENGKHLS EEDLKELAED AEQRVSGEPQ
     PSYFKEVF