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AGAL1_PEDPE
ID   AGAL1_PEDPE             Reviewed;         733 AA.
AC   P43467;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Alpha-galactosidase 1;
DE            EC=3.2.1.22;
DE   AltName: Full=Melibiase;
GN   Name=agaR;
OS   Pediococcus pentosaceus.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Pediococcus.
OX   NCBI_TaxID=1255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PPE1.0;
RA   Leenhouts K.K.J., Bolhuis A.A., Kok J.J., Venema G.G.;
RT   "The sucrose and raffinose operons of Pediococcus pentosaceus PPE1.0.";
RL   Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Alpha-galactosidase associated with the raffinose operon.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing alpha-D-galactose
CC         residues in alpha-D-galactosides, including galactose
CC         oligosaccharides, galactomannans and galactolipids.; EC=3.2.1.22;
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 36 family. {ECO:0000305}.
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DR   EMBL; Z32771; CAA83665.1; -; Genomic_DNA.
DR   EMBL; L32093; AAA25564.1; -; Genomic_DNA.
DR   PIR; S44254; S44254.
DR   RefSeq; WP_056979569.1; NZ_WEOZ01000006.1.
DR   AlphaFoldDB; P43467; -.
DR   SMR; P43467; -.
DR   CAZy; GH36; Glycoside Hydrolase Family 36.
DR   GO; GO:0052692; F:raffinose alpha-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR   CDD; cd14791; GH36; 1.
DR   Gene3D; 2.60.40.1180; -; 1.
DR   Gene3D; 2.70.98.60; -; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR038417; Alpga-gal_N_sf.
DR   InterPro; IPR000111; Glyco_hydro_27/36_CS.
DR   InterPro; IPR002252; Glyco_hydro_36.
DR   InterPro; IPR031705; Glyco_hydro_36_C.
DR   InterPro; IPR031704; Glyco_hydro_36_N.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   Pfam; PF16874; Glyco_hydro_36C; 1.
DR   Pfam; PF16875; Glyco_hydro_36N; 1.
DR   PIRSF; PIRSF005536; Agal; 1.
DR   PRINTS; PR00743; GLHYDRLASE36.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS00512; ALPHA_GALACTOSIDASE; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase.
FT   CHAIN           1..733
FT                   /note="Alpha-galactosidase 1"
FT                   /id="PRO_0000134874"
FT   ACT_SITE        480
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:Q9ALJ4"
FT   ACT_SITE        550
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9ALJ4"
SQ   SEQUENCE   733 AA;  83314 MW;  7732ACFDB655EE88 CRC64;
     MSLITVDQAN RVFHLHNQTL SYIFAVEQGG TLSHLYFGGH VDHYHGELRY PRVDRGFSGN
     LPGSTDRTFS RDTLPKEYST AGEMDYHLPA AIVRHTDGAN ALYLVYQGYR IEAGKPKLSG
     LPAAFVEDET EAETLTIVLV DQVSQVEFDL QYTIYRDRPV VTRSVQVCNQ GDHAVNLEKV
     ASMQIDFTDR QFETITLPGA HANERHPERG SINYGIQTFG SLRGTSSHQM NPFLALVDHT
     TTEFSGDAYG FNLVYSGNHA FELEKDQLDQ LHLMVGINSY NFNWQLKAGA TFQTPEVLMV
     YTNKGLNAMS QAYHHLIRER VVRSEFKNQE RPIVVNNWEA TFFDFNEAKL KPIVDEAKQL
     GIEMFVLDDG WFGHRDDDNS SLGDWQVDHR KFPQGLNHFV KYVHEQGLKF GIWLEPEMIS
     YDSKLYQQHP DYLMQVPGRS PSPSRNQYIL DLGRQAVRNN IFDQLDQLLK SKQIDYIKWD
     MNRHLSDIYS VALPPERQGE VYHRYVLGLY ELLERLTTAY PHILFEGCSG GGGRFDAGMA
     YYMPQIWASD NTDAVARLTI QYGTSLAYPI SLATAHVSVS PNQQTGRETS MSTRSAVAAS
     GVLGYELDLT QLSSADKQIV QKQVVQYKQI RPLIQFGEFY RLKSPITSNQ AAWMFVSPQQ
     DEAIVMVFNL TSYAQPSLTK TKLVGLNPKL NYQNIATKAI FGGDELMQLG FYDPVVYQDY
     TTKVYHFKAV TEN
 
 
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