ID   EKI2_RAT                Reviewed;         385 AA.
AC   D3ZRW8; D4A6J5;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Ethanolamine kinase 2;
DE            Short=EKI 2;
DE            EC=2.7.1.82;
DE   AltName: Full=Ethanolamine kinase-like protein;
GN   Name=Etnk2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Highly specific for ethanolamine phosphorylation. Does not
CC       have choline kinase activity.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + ethanolamine = ADP + H(+) + phosphoethanolamine;
CC         Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216;
CC         EC=2.7.1.82;
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC       biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC   -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDM09769.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EDM09770.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH473958; EDM09769.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH473958; EDM09770.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_001101813.1; NM_001108343.1.
DR   AlphaFoldDB; D3ZRW8; -.
DR   SMR; D3ZRW8; -.
DR   STRING; 10116.ENSRNOP00000061210; -.
DR   PaxDb; D3ZRW8; -.
DR   PeptideAtlas; D3ZRW8; -.
DR   GeneID; 360843; -.
DR   KEGG; rno:360843; -.
DR   UCSC; RGD:1305304; rat.
DR   CTD; 55224; -.
DR   RGD; 1305304; Etnk2.
DR   eggNOG; KOG4720; Eukaryota.
DR   InParanoid; D3ZRW8; -.
DR   OMA; MDWLKEY; -.
DR   OrthoDB; 349250at2759; -.
DR   PhylomeDB; D3ZRW8; -.
DR   TreeFam; TF313549; -.
DR   Reactome; R-RNO-1483213; Synthesis of PE.
DR   UniPathway; UPA00558; UER00741.
DR   PRO; PR:D3ZRW8; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Proteomes; UP000234681; Chromosome 13.
DR   Bgee; ENSRNOG00000028368; Expressed in liver and 17 other tissues.
DR   ExpressionAtlas; D3ZRW8; baseline and differential.
DR   Genevisible; D3ZRW8; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004305; F:ethanolamine kinase activity; ISO:RGD.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:0035264; P:multicellular organism growth; ISO:RGD.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; ISO:RGD.
DR   GO; GO:0016310; P:phosphorylation; ISO:RGD.
DR   GO; GO:0001890; P:placenta development; ISO:RGD.
DR   GO; GO:0009791; P:post-embryonic development; ISO:RGD.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Lipid biosynthesis; Lipid metabolism;
KW   Nucleotide-binding; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..385
FT                   /note="Ethanolamine kinase 2"
FT                   /id="PRO_0000395963"
SQ   SEQUENCE   385 AA;  44734 MW;  E27F27544301550B CRC64;
     MAVPPSAPVP CSPFYLRRQE ACPQCSWSME EKAVASASCW EPPGPPRAAV PCFAIAVDQD
     DILPGALRLI RELRPHWKPE QVRTKRFKDG ITNKLLACYV EEDMRDCVLV RVYGEWTELL
     VDRENEIRNF QLLRAHGCAP KLYCTFQNGL CYEYMQGVAL GPEHIREPQL FRLIALEMAK
     IHTIHANGSL PKPTLWHKMH RYFTLVKDEI SPSLSADVPK VEVLEQELAW LKEHLSQLDS
     PVVFCHNDLL CKNIIYDSDK GHVRFIDYEY AGYNYQAFDI GNHFNEFAGV NEVDYCRYPA
     REIQLQWLRY YLEAQKGTAA SPREVERLYA QVNKFALASH FFWALWALIQ NQYSTINFDF
     LRYAVIRFNQ YFKVKPQVSA LEMPK