ID   EKIA_DICDI              Reviewed;         349 AA.
AC   Q869T9; Q554V5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Probable ethanolamine kinase A;
DE            EC=2.7.1.82;
GN   Name=etnkA; ORFNames=DDB_G0274955;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Highly specific for ethanolamine phosphorylation. May be a
CC       rate-controlling step in phosphatidylethanolamine biosynthesis (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + ethanolamine = ADP + H(+) + phosphoethanolamine;
CC         Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216;
CC         EC=2.7.1.82;
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC       biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000012; EAL70370.1; -; Genomic_DNA.
DR   RefSeq; XP_644218.1; XM_639126.1.
DR   AlphaFoldDB; Q869T9; -.
DR   SMR; Q869T9; -.
DR   STRING; 44689.DDB0267033; -.
DR   PaxDb; Q869T9; -.
DR   EnsemblProtists; EAL70370; EAL70370; DDB_G0274955.
DR   GeneID; 8619647; -.
DR   KEGG; ddi:DDB_G0274955; -.
DR   dictyBase; DDB_G0274955; etnkA.
DR   eggNOG; KOG4720; Eukaryota.
DR   HOGENOM; CLU_012712_1_0_1; -.
DR   InParanoid; Q869T9; -.
DR   OMA; FKMKPEA; -.
DR   PhylomeDB; Q869T9; -.
DR   Reactome; R-DDI-1483191; Synthesis of PC.
DR   Reactome; R-DDI-1483213; Synthesis of PE.
DR   UniPathway; UPA00558; UER00741.
DR   PRO; PR:Q869T9; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004305; F:ethanolamine kinase activity; IBA:GO_Central.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Lipid biosynthesis; Lipid metabolism;
KW   Nucleotide-binding; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..349
FT                   /note="Probable ethanolamine kinase A"
FT                   /id="PRO_0000332721"
SQ   SEQUENCE   349 AA;  40902 MW;  4DAD07ACCC8E7B5B CRC64;
     MMAKTKGSYE VFHYTVTKDK VNKGLCDIAR YFVPEYRNSK DEDLTIQKLN GGITNVLYLV
     EDKNIEQKYR YLPVVIRLYG YKSEEIIDRK NELIIQTEAD QNGLGAKFYG LFDNGCIYGF
     IKGEPLAYED ISKPTMQTCI AKEIAQWHSI EMPTRKNPSL WPTIKKWAAL APDVYPVPEK
     NEYYQSINVK KMIEEGKMLE QRLAQLNSPI VFCHNDLLSG NIIYDPSQNC ASFIDFEYAN
     YNFRGLELGN HFNEYAGFGP DYSLYPNKES QIHFLTDYHR SLFKTEPTQD ELEKLYIESN
     QFSLASHLYW GFWAIVQAMN SQIDFDYLEY GKARFDRYYE TRDQFLNLN