ID   EKIB_DICDI              Reviewed;         447 AA.
AC   Q554D8; Q869W4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Probable ethanolamine kinase B;
DE            EC=2.7.1.82;
GN   Name=etnkB; ORFNames=DDB_G0275265;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Highly specific for ethanolamine phosphorylation. May be a
CC       rate-controlling step in phosphatidylethanolamine biosynthesis (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + ethanolamine = ADP + H(+) + phosphoethanolamine;
CC         Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216;
CC         EC=2.7.1.82;
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC       biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000013; EAL69913.1; -; Genomic_DNA.
DR   RefSeq; XP_643773.1; XM_638681.1.
DR   AlphaFoldDB; Q554D8; -.
DR   SMR; Q554D8; -.
DR   STRING; 44689.DDB0267034; -.
DR   PaxDb; Q554D8; -.
DR   EnsemblProtists; EAL69913; EAL69913; DDB_G0275265.
DR   GeneID; 8619818; -.
DR   KEGG; ddi:DDB_G0275265; -.
DR   dictyBase; DDB_G0275265; etnkB.
DR   eggNOG; KOG2686; Eukaryota.
DR   HOGENOM; CLU_012712_1_0_1; -.
DR   InParanoid; Q554D8; -.
DR   OMA; HEWTADY; -.
DR   PhylomeDB; Q554D8; -.
DR   Reactome; R-DDI-1483191; Synthesis of PC.
DR   Reactome; R-DDI-1483213; Synthesis of PE.
DR   UniPathway; UPA00558; UER00741.
DR   PRO; PR:Q554D8; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004305; F:ethanolamine kinase activity; IBA:GO_Central.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Lipid biosynthesis; Lipid metabolism;
KW   Nucleotide-binding; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..447
FT                   /note="Probable ethanolamine kinase B"
FT                   /id="PRO_0000332722"
FT   REGION          178..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   447 AA;  51439 MW;  B344650C8CFD91D7 CRC64;
     MNEFEDIIYP GPSHVTTNIE FEDENIENNE NYLNLVQILK ELVDNNLKEE IEFKPMVGGV
     TNTLFKSSFI TGQGSNKSVI IRLYGKGSEQ FIDRKTEANI QYLLSKNGVG PKFYGTFENG
     CIYGYVEGDQ LQLEDLYQNN ILSLIAKETG RWHSLKLDIN SNSQLLLSSS SDSSIKESTT
     ISTSTSTSTS TSSTSPSTSP SLENSTLSPR NMNTQTSSTS LFKNLNSWIN NAMTLTSKES
     KGSMISKINL NRYKEEAMSL MSFIEEHYSG EEYINFCHND LIPRNMIYNK EKGQVKFIDF
     EYSGYNFRGY DIGNFFCEFS GLDLDYTKYP SIEIQKRFIK NYLISINNCK NIQQKQKQKQ
     QQQQIQNSIN DENMDIENDE LLYEPSKEEI HNLYIESNHL TLGSHLMWGF WGIIQHFSSS
     IDFDYIDYAI KRFKQYDLVK NKVLSLK